Association between kidney function and intracerebral hematoma volume
Association between kidney function and intracerebral hematoma volume
复制标题
肾功能与脑内血肿量的关系
DOI：
10.1016/j.jocn.2021.12.022
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发表时间：
2022
影响因子：
2
通讯作者：
Mochizuki Hideki
中科院分区：
文献类型：
--
作者：
Gon Yasufumi;Kabata Daijiro;Mochizuki Hideki
据报道，由于营养失衡和血小板功能障碍，肾功能障碍与脑出血（ICH）中较大的血肿量有关；然而，这种联系仍然存在争议。本研究分析了脑出血患者潜在危险因素与血肿量之间的关系。这项回顾性队列研究使用了来自单一综合卒中中心的456例脑出血患者的数据。我们使用多变量非线性回归模型评估估计肾小球滤过率（eGFR）和控制营养状态评分与血肿体积的关系。使用结果自适应双/去偏机器学习方法，考虑许多协变量，分析使用抗血栓药物对血肿体积的影响。年龄和eGFR的中位数和四分位数范围分别为64（54-75）岁和56.1 (39.3-66.7)mL/min/1.73 m2。多变量非线性回归模型显示：(1)eGFR与血肿体积呈线性正相关，但无统计学意义；(2)营养状况与血肿体积呈正相关，但不显著。结果适应性双/去偏机器学习显示，接受抗血栓药物治疗的患者血肿体积并不明显大于未接受抗血栓药物治疗的患者（估计血肿体积的平均差异[95%置信区间]= 15.32[- 6.02至36.65]）。我们的分析显示，肾功能和血肿量之间没有统计学或临床意义的关系；然而，营养状况和抗血栓药物的使用显示脑出血患者血肿程度增加的趋势。
Renal dysfunction has been reported to be associated with larger hematoma volume in intracerebral hemorrhage (ICH) due to concomitant nutritional imbalances and platelet dysfunction; however, this association remains controversial. This study analyzed the association between potential risk factors and hematoma volume in patients with ICH. This retrospective cohort study used data from 456 patients with ICH at a single comprehensive stroke center. We assessed the association of estimated glomerular filtration rate (eGFR) and Controlling Nutritional Status score with hematoma volume using multivariable non-linear regression models. The effect of the use of antithrombotic agents on hematoma volume was analyzed using outcome-adaptive double/debiased machine learning approach, considering many covariates. The median and interquartile range of age and eGFR were 64 (54–75) years and 56.1 (39.3–66.7) mL/min/1.73 m2, respectively. The multivariable non-linear regression model showed that (1) eGFR and hematoma volume had a positive linear association, which was not statistically significant, and (2) nutritional status was positively associated with hematoma volume, although not significantly. Outcome-adaptive double/debiased machine learning revealed that patients receiving antithrombotic agents did not present with significantly larger hematoma volume than those who were not receiving antithrombotic agents (estimated mean difference of hematoma volume [95% confidence interval] = 15.32 [−6.02 to 36.65]). Our analysis shows no statistically or clinically significant relationship between renal function and hematoma volume; however, nutritional status and the use of antithrombotic agents showed an increasing tendency of the degree of hematoma in patients with ICH.
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影响因子：
8.3
作者：
Li, Qi;Liu, Qing-Jun;Xie, Peng
通讯作者：
Xie, Peng
影响因子：
29
作者：
Boulouis G;Morotti A;Brouwers HB;Charidimou A;Jessel MJ;Auriel E;Pontes-Neto O;Ayres A;Vashkevich A;Schwab KM;Rosand J;Viswanathan A;Gurol ME;Greenberg SM;Goldstein JN
通讯作者：
Goldstein JN
DOI：
10.1016/s0021-9258(17)44308-0
发表时间：
1983-10
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
N. Tandon;J. Harmon;D. Rodbard;G. Jamieson
通讯作者：
N. Tandon;J. Harmon;D. Rodbard;G. Jamieson
影响因子：
5.9
作者：
Zha Y;Qian Q
通讯作者：
Qian Q
影响因子：
10.7
作者：
Chernozhukov, Victor;Chetverikov, Denis;Newey, Whitney
通讯作者：
Newey, Whitney