Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender.
Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender.
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DOI：
10.1186/1471-2458-9-481
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发表时间：
2009-12-21
影响因子：
4.5
通讯作者：
Adler GK
中科院分区：
文献类型：
--
作者：
Kubzansky LD;Mendes WB;Appleton A;Block J;Adler GK
大量的经验证据表明，被社会孤立或几乎没有积极社会关系的人似乎衰老得更快，患上更多的慢性病。催产素是一种神经垂体激素，被假设为协调积极社会互动的原因和结果，并可能参与积极的生理适应，如缓冲压力的有害影响和增强韧性。这项拟议的研究将研究催产素是否以及如何影响人类对压力的反应，并将考虑与社会支持相关的影响。实验研究将用于确定在成年后，在不同性别和年龄的压力条件下，外源性给予催产素(鼻内)是否会影响心理和生理结果。有待检验的假设是：1)催产素可以改善有害的神经内分泌、心血管和压力的主观影响；2)催产素和社会支持具有相似和相加的压力缓冲作用；3)女性的催产素作用比男性更强；4)催产素的作用在不同的成年年龄范围内是相似的。假说将通过一项安慰剂对照的双盲研究来验证，该研究使用了从社区招募的健康男性和女性的样本。参与者被随机分配接受催产素或安慰剂。他们接受了有社会支持和没有社会支持的社会压力操纵(随机分配)，并在过程中多次获得结果测量。了解健康老龄化的决定因素是公共卫生的主要优先事项，确定有效措施预防或推迟慢性病的发生是一个重要目标。关于成年后催产素、社会关系和健康的实验研究将有助于为最大化活动寿命和健康预期提供科学知识基础。在研究结束时，我们将得到关于催产素对压力反应的影响的确凿证据，以及它是否在年龄和性别群体中具有类似的影响。对恢复力的神经生物学理解可以为预防和干预以后生活中常见的疾病或问题提供信息。临床试验识别号为NCT01011465。
Substantial empirical evidence has demonstrated that individuals who are socially isolated or have few positive social connections seem to age at a faster rate and have more chronic diseases. Oxytocin is a neurohypophyseal hormone hypothesized to coordinate both the causes and effects of positive social interactions, and may be involved in positive physiological adaptations such as buffering the deleterious effects of stress and promoting resilience. The proposed research will examine whether and how oxytocin influences responses to stress in humans and will consider effects in relation to those of social support. Experimental research will be used to determine whether exogenously administered oxytocin (intranasal) influences psychological and physiological outcomes under conditions of stress across gender and age in adulthood. Hypotheses to be tested are: 1) Oxytocin ameliorates the deleterious neuroendocrine, cardiovascular, and subjective effects of stress; 2) Oxytocin and social support have similar and additive stress-buffering effects; 3) Oxytocin effects are stronger in women versus men; and 4) Oxytocin effects are similar across a range of adult ages. Hypotheses will be tested with a placebo-controlled, double-blind study using a sample of healthy men and women recruited from the community. Participants are randomly assigned to receive either oxytocin or placebo. They undergo a social stress manipulation with and without social support (randomly assigned), and outcome measures are obtained at multiple times during the procedure. Understanding the determinants of healthy aging is a major public health priority and identifying effective measures to prevent or delay the onset of chronic diseases is an important goal. Experimental research on oxytocin, social relationships, and health in adulthood will contribute to the scientific knowledge base for maximizing active life and health expectancy. At conclusion of the study we will have solid evidence concerning the effects of oxytocin on stress response and whether it has similar effects across age and gender groups. A neurobiological understanding of resilience can inform efforts for both prevention and intervention of diseases or problems common in later life. Clinical trial identification number is NCT01011465.