Onset of clinical immunity to Plasmodium falciparum among Javanese migrants to Indonesian Papua
Onset of clinical immunity to Plasmodium falciparum among Javanese migrants to Indonesian Papua
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DOI：
10.1179/000349803225001472
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发表时间：
2003-09-01
影响因子：
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通讯作者：
Kalalo, W
中科院分区：
文献类型：
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作者：
Baird, JK;Krisin;Kalalo, W
爪哇移民对印尼巴布亚邦的移民发生了对恶性疟原虫的临床免疫的发作。对243名移民的监视始于他们到达印度尼西亚巴布亚的当天，并持续了33个月。无热的无性寄生虫血症构成临床免疫的客观证据。与第一次感染相比，在24个月内未发烧的优势比（OR）为3.2 [95％置信区间（CI）= 1.03-10.2; p = 0.02]。 24个月内相应的感染或较少感染与1.0无法区分。在24个月内（n = 58）内第四次寄生虫血症的水平被归类为首先感染时中位数的“高”或“低”（840寄生虫/mul; n = 187）。第四个寄生虫 - 但不高的寄生虫（OR = 1.8; CI -0.6-5.4; P = 0.35）与发烧的巨大保护有关（OR = 31; CI = 3.5-1348; P = 0.0001） 。在成年受试者中，初次感染低寄生虫血症发烧的风险明显高于第四个感染（OR = 12.6; Cl = 1.7-530; P = 0.005），表明临床免疫的发展。在研究的儿童中出现了类似但标记的模式（OR = 6.5; CI = 0.8-285; p = 0.06）。
Onset of clinical immunity to Plasmodium falciparum occurred among Javanese migrants to Indonesian Papua. Surveillance of the 243 migrants investigated began on the day of their arrival in Indonesian Papua and continued for 33 months. Asexual parasitaemia without fever constituted objective evidence of clinical immunity. Compared with first infection, the odds ratio (OR) for not having fever at the fourth infection within 24 months was 3.2 [95% confidence interval (CI) = 1.03-10.2; P = 0.02]. The corresponding OR with fewer infections within 24 months was not distinguishable from 1.0. The level of the fourth parasitaemia within 24 months (N = 58) was classified as 'high' or 'low' in relation to the median count at first infection (840 parasites/mul; N = 187). Fourth parasitaemias that were low - but not those that were high (OR = 1.8; CI - 0.6-5.4; P = 0.35) - were associated with dramatic protection from fever (OR = 31; CI = 3.5-1348; P=0.0001). Among the adult subjects, the risk of fever with low parasitaemia was significantly higher at the first infection than at the fourth (OR = 12.6; Cl = 1.7-530; P = 0.005), indicating the development of clinical immunity. A similar but less marked pattern appeared among the children investigated (OR = 6.5; CI = 0.8-285;P = 0.06).