PHOSPHATIDYLCHOLINE COMPOSITION OF ENDOTRACHEAL-TUBE ASPIRATES OF NEONATES AND SUBSEQUENT RESPIRATORY-DISEASE
PHOSPHATIDYLCHOLINE COMPOSITION OF ENDOTRACHEAL-TUBE ASPIRATES OF NEONATES AND SUBSEQUENT RESPIRATORY-DISEASE
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DOI：
10.1136/adc.67.4_spec_no.378
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发表时间：
1992-04-01
影响因子：
4.4
通讯作者：
NORMAND, ICS
中科院分区：
文献类型：
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作者：
ASHTON, MR;POSTLE, AD;NORMAND, ICS
采用高效液相色谱法和柱后荧光衍生法测定105例因呼吸窘迫综合征而插管复苏或通气的新生儿气管内吸出液中磷脂酰胆碱（PC）的含量。68例PC可测量。在发生呼吸窘迫综合征的婴儿中，无论是否伴有慢性肺部疾病，双棕榈酰磷脂酰胆碱（DPPC）的百分比或DPPC与棕榈酰磷脂酰胆碱（POPC）的比率都没有显示出与胎龄的任何相关性。然而，这两个参数在这组婴儿中都明显低于未发生呼吸窘迫综合征的婴儿组。无论胎龄大小，DPPC:POPC比值< 3.0的婴儿均发生呼吸窘迫综合征，但大于此值的组间有相当大的重叠。患有呼吸窘迫综合征并发展为慢性肺病的婴儿与那些没有发展为慢性肺病的呼吸窘迫综合征婴儿具有相同的初始PC特征，但作为一组不同的是，他们更轻，更早产。慢性肺部疾病的发展与特定的初始PC成分无关。因此，与早产增加有关的其他因素必然与使婴儿易患慢性肺病有关。
The phosphatidylcholine (PC) content of the initial endotracheal tube aspirate was measured in 105 infants intubated for resuscitation or for ventilation for respiratory distress syndrome, using high performance liquid chromatography and postcolumn fluorescence derivitisation with diphenyl-1,3,5-hexatriene. Sixty eight had measurable PC. Of the infants who developed respiratory distress syndrome, with or without subsequent chronic lung disease, neither the percentage of dipalmitoylphosphatidylcholine (DPPC) nor the ratio of DPPC to palmitoyloleoylphosphatidylcholine (POPC), showed any correlation with gestational age. However, both parameters were significantly lower overall in this group than in the group of infants who did not develop respiratory distress syndrome. Infants with a ratio of DPPC:POPC < 3.0 developed respiratory distress syndrome irrespective of gestational age, but there was considerable overlap between groups for values greater than this.The infants with respiratory distress syndrome who went on to develop chronic lung disease had the same initial PC profile as those with respiratory distress syndrome who did not develop chronic lung disease, but differed as a group by being lighter and more premature. The development of chronic lung disease was not associated with a particular initial PC composition. Other factors related to increasing prematurity must therefore be involved in rendering infants vulnerable to developing chronic lung disease.