Conjugated linoleic acid and inflammatory cell signalling
Conjugated linoleic acid and inflammatory cell signalling
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DOI：
10.1016/j.plefa.2010.02.021
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发表时间：
2010-04-01
影响因子：
3
通讯作者：
Roche, H. M.
中科院分区：
文献类型：
--
作者：
Reynolds, C. M.;Roche, H. M.
共轭亚油酸（CLA）是多不饱和脂肪酸（PUFA）的一个家族，一些异构体天然存在于牛肉和乳制品中，另一些是植物油双氢化形成人造黄油的结果。合成和天然来源的CLA可能在一系列炎症性疾病中具有有益作用，包括结肠炎、动脉粥样硬化、代谢综合征和类风湿性关节炎。大多数生物效应归因于顺式9，反式11-（c9，t11-）和反式10，顺式12-（t10，c12-）异构体。有证据表明，c9，t11-CLA负责归因于CLA的抗炎作用，而t10，t12-CLA似乎负责抗脂肪形成作用。本文就CLA在细胞、系统和临床水平上对胰岛素抵抗、动脉粥样硬化和Th 1介导的炎症性疾病相关炎症组分的影响作一综述。虽然CLA可以改善炎症反应的某些方面，特别是在细胞和动物模型中，但在人类健康的背景下，其相关性还有待澄清。(C)2010爱思唯尔有限公司版权所有。
Conjugated linoleic acids (CLA) are a family of polyunsaturated fatty acids (PUFA), some isomers occurring naturally in beef and dairy products and others being formed as a result of bihydrogenation of vegetable oils to form margarine. Synthetic and natural sources of CLA may have beneficial effects in a range of inflammatory conditions including colitis, atherosclerosis, metabolic syndrome and rheumatoid arthritis. Most of the biological effects have been attributed to the cis9, trans11-(c9, t11-) and the trans10, cis12- (t10, c12-) isomers. Evidence suggests that c9, t11-CLA is responsible for the anti-inflammatory effect attributed to CLA while t10, t12-CLA appears to be responsible for anti-adipogenic effects. This review will focus on the effects of CLA on the inflammatory components associated with insulin resistance, atherosclerosis and Th1 mediated inflammatory disease, at a cellular, systemic and clinical level. Whist CLA may ameliorate certain aspects of the inflammatory response, particularly within cellular and animal models, the relevance of this has yet to be clarified within the context of human health. (C) 2010 Elsevier Ltd. All rights reserved.