Evaluation of time domain and spectral domain optical coherence tomography in the measurement of diabetic macular edema
Evaluation of time domain and spectral domain optical coherence tomography in the measurement of diabetic macular edema
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DOI：
10.1167/iovs.08-2113
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发表时间：
2008-10-01
影响因子：
4.4
通讯作者：
Wong, Wai T.
中科院分区：
文献类型：
--
作者：
Forooghian, Farzin;Cukras, Catherine;Wong, Wai T.
目的。在糖尿病性黄斑水肿（DME）的背景下，评估两种光学相干断层扫描（OCT）系统：时域系统Stratus OCT和光谱域系统Cirrus HD-OCT的黄斑厚度和体积测量及其内重复性（均由Carl Zeiss Meditec， Inc., Dublin， CA）。对33例伴有临床显著黄斑水肿（CSME）的糖尿病患者的33只眼进行了一次扫描，由一名操作员在两套OCT系统上进行扫描。对9个标准黄斑亚场的黄斑厚度和黄斑总体积进行了测量和分析。构建Bland-Altman图来评估黄斑测量的一致性。采用组内相关系数（ICCs）、重复性系数（CRW）和变异系数（CVW）评价组内重复性。Cirrus HD-OCT系统的9个视网膜亚场的黄斑厚度和黄斑体积明显高于Stratus OCT系统。与Stratus OCT系统相比，Cirrus HD-OCT系统的子田厚度和总体积测量值分别大30 ~ 55 μ m和3.2 mm(3)。层云OCT和卷云HD-OCT系统都显示出高的侵入重复性，具有CRW、CVW和ICC的重叠范围。重复性测量（CRW和CVW）在九个子场（外时间子场）中只有一个在不同系统之间存在显著差异。DME患者黄斑厚度和体积的绝对测量值在层状OCT和卷状HD-OCT系统之间有显著差异。然而，两种OCT系统均表现出较高的专业内重复性。虽然这两种系统可能不能互换使用，但它们在临床实践和研究中产生黄斑测量时似乎同样可靠。
PURPOSE. To evaluate macular thickness and volume measurements and their intrasession repeatability in two optical coherence tomography (OCT) systems: the Stratus OCT, a time domain system, and the Cirrus HD-OCT, a spectral domain system (both by Carl Zeiss Meditec, Inc., Dublin, CA), in the context of diabetic macular edema (DME).METHODS. Thirty-three eyes of 33 diabetic patients with clinically significant macular edema (CSME) were scanned in a single session by a single operator on both OCT systems. Macular thickness measurements of nine standard macular sub-fields and total macular volume were obtained and analyzed. Bland-Altman plots were constructed to assess agreement in macular measurements. Intraclass correlation coefficients (ICCs), coefficients of repeatability (CRW), and coefficients of variation (CVW) were used to assess intrasession repeatability.RESULTS. Macular thickness in nine retinal subfields and macular volume were significantly higher in the Cirrus HD-OCT system compared with the Stratus OCT system. Subfield thickness and total volume measurements, respectively, were 30 to 55 mu m and 3.2 mm(3) greater for the Cirrus HD-OCT system compared with the Stratus OCT system. Both Stratus OCT and Cirrus HD-OCT systems demonstrated high intrasession repeatability, with overlapping ranges for CRW, CVW, and ICC. Repeatability measures (CRW and CVW) differed significantly between systems in only one of nine subfields (outer temporal subfield).CONCLUSIONS. Absolute measures of macular thickness and volume in patients with DME differed significantly in magnitude between the Stratus OCT and Cirrus HD-OCT systems. However, both OCT systems demonstrated high intrasessional repeatability. Although the two systems may not be used interchangeably, they appear equally reliable in generating macular measurements for clinical practice and research.