Age and secular trends in bone lead levels in middle-aged and elderly men: Three-year longitudinal follow-up in the normative aging study
Age and secular trends in bone lead levels in middle-aged and elderly men: Three-year longitudinal follow-up in the normative aging study
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DOI：
10.1093/oxfordjournals.aje.a009318
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发表时间：
1997-10-01
影响因子：
5
通讯作者：
Hu, H
中科院分区：
文献类型：
--
作者：
Kim, R;Landrigan, C;Hu, H
这项研究的目的是检查年龄和长期趋势的骨和血铅水平的社区暴露的男子。在一项关于衰老的纵向研究中，对参与者的骨铅和血铅水平进行了两次测量，两次测量之间间隔3年。70名受试者（平均年龄= 66岁，年龄范围= 52-83岁）进行了研究，重复测量骨和血铅水平。在首次评价时，髌骨、胫骨和血液中的几何平均铅水平分别为29.1（标准差（SD）1.8）μ g/g、17.5（SD 2.0）μ g/g和6.7（SD 1.8）μ g/dl。在第二次评价时，这些水平分别为22.2（SD 1.8）μ g/g、17.9（SD 1.7）μ g/g和5.1（SD 1.4）μ g/dl。每组测量值的横截面分析表明，平均而言，1岁的个体髌骨和胫骨中的铅水平分别高出2.7%和2.4-3.2%。与横断面分析中的年龄增长趋势相反，髌骨电极导线水平随时间的长期趋势是下降的，胫骨电极导线水平稳定。作者得出结论，在社区暴露的中年和老年男性中，自20世纪90年代初以来，髌骨和血液中铅暴露的生物标志物正在减少，胫骨中的生物标志物没有变化。应根据出生队列效应仔细解释横断面研究中骨铅水平的年龄增长趋势。
The goal of this study was to examine age and secular trends in bone and blood lead levels of community-exposed men. Bone and blood lead levels were measured twice, with a 3-year interval between measurements, among participants in a longitudinal study of aging. Seventy subjects (mean age = 66 years, age range = 52-83 years) with repeated measurements of bone and blood lead levels were studied. At the first evaluation, geometric mean lead levels in patella, tibia, and blood were 29.1 (standard deviation (SD) 1.8) mu g/g, 17.5 (SD 2.0) mu g/g, and 6.7 (SD 1.8) mu g/dl, respectively. At the second evaluation, these levels were 22.2 (SD 1.8) mu g/g, 17.9 (SD 1.7) mu g/g, and 5.1 (SD 1.4) mu g/dl, respectively. Cross-sectional analysis of each set of measurements indicated that, on average, a 1-year-older individual would have 2.7% and 2.4-3.2% higher levels of lead in patella and tibia, respectively. In contrast to the increasing age trend in cross-sectional analysis, the secular trend over time was decreasing for patella lead levels and stable for tibia lead levels. The authors conclude that in community-exposed middle-aged and elderly men, the biomarkers of exposure to lead are decreasing in patella and blood and unchanging in tibia as of the early 1990s. The increasing age trend in bone lead levels in cross-sectional studies should be carefully interpreted in light of the birth cohort effect.