MORPHOMETRIC STUDIES OF NEUROPATHOLOGICAL CHANGES IN CHOREATIC DISEASES
MORPHOMETRIC STUDIES OF NEUROPATHOLOGICAL CHANGES IN CHOREATIC DISEASES
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DOI：
10.1016/0022-510x(76)90114-3
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发表时间：
1976-01-01
影响因子：
4.4
通讯作者：
SCHRODER, KF
中科院分区：
文献类型：
--
作者：
LANGE, H;THORNER, G;SCHRODER, KF
应用形态计量学方法对13例正常成人和15例舞蹈病患者的纹状体、苍白球和丘脑底核进行了连续切片研究。测量大脑半球和皮质的体积。获得的所有数据通过收缩因子校正以代表新鲜脑值。在亨廷顿舞蹈病中，苍白球受到的影响比通常认为的要严重。纹状体的平均体积减少程度相同（外侧-57%，内侧-50%）（-56%）。苍白球神经细胞的绝对数量减少了约40%，在这两个部分。丘脑底核神经细胞的体积和数量减少约25%。在所研究的3个皮质下核中，神经细胞的平均体积没有减少。纹状体中胶质细胞的绝对数量没有增加。胶质细胞数密度增加是由于萎缩所致。苍白球和丘脑底核神经细胞的丢失主要是由初级过程引起的。亨廷顿舞蹈病是一个多灶性的过程。形态测量数据并不表明亚舞蹈病是亨廷顿舞蹈病的一种变异。舞蹈症被认为是一个多灶性的过程，不同的痛苦，纹状体，苍白球和丘脑底核。在这种疾病中发现了胶质细胞数量的增加和神经细胞的中度损失。
The striatum, pallidum and subthalamic nucleus were studied by combined morphometric methods in serial sections of 13 brains of normal adults and of 15 patients with choreatic diseases. The volume of the hemispheres and of the cortex were measured. All data obtained were corrected by the shrinkage factor to represent fresh brain values. In Huntington''s chorea the pallidum was more severely affected than is commonly appreciated. The average volume reduction was of the same degree (lateral -57%, medial -50%) as that of the striatum (-56%). The absolute number of nerve cells of the pallidum decreased in both segments by about 40%. The reduction of the volume and of the number of nerve cells of the subthalamic nucleus was about 25%. The average volume of nerve cells was not reduced in the 3 subcortical nuclei studied. There was no increase in the absolute number of glial cells in the striatum. The increased numerical density of glial cells was caused by shrinkage. The loss of nerve cells of the pallidum and subthalamic nucleus was caused mainly by a primary process. Huntington''s chorea is a multifocal process. Morphometric data did not suggest that subchorea is a variant of Huntington''s chorea. Chorea minor is regarded as a multifocal process with varying affliction of the striatum, pallidum and subthalamic nucleus. An increase in the number of glial cells and a moderate loss of nerve cells were found in this disease.