Canalization and developmental stability in the Brachyrrhine mouse.
Canalization and developmental stability in the Brachyrrhine mouse.
复制标题
Brachyrhin 小鼠的管道化和发育稳定性。
DOI：
10.1111/j.1469-7580.2006.00527.x
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发表时间：
2006
影响因子：
2.4
通讯作者：
Hallgrímsson,Benedikt
中科院分区：
文献类型：
--
作者：
Willmore,KatherineElizabeth;Zelditch,MiriamLeah;Young,Nathan;Ah-Seng,Andrew;Lozanoff,Scott;Hallgrímsson,Benedikt
半显性Br突变影响蝶骨前生长，产生杂合子特征性的面颌后缩和球状神经颅穹窿。我们分析了这种突变对颅骨形状的影响，将杂合子与野生型小鼠进行比较，以确定这种影响是全颅骨的还是仅限于突变靶向的蝶骨区域。此外，我们还研究了颅骨作为一个整体和三个区域（基底颅，面和脑颅）的形状变化模式。我们发现Brmice在所有三个区域的头骨形状以及整个头骨的形状上与野生型小鼠有显着差异。然而，方差和波动的不对称性的显着增加，发现只有在基颅突变小鼠。这些结果表明，突变有一个显着的影响，对潜在的发展架构的头骨，这产生了增加表型变异，是本地化的解剖区域，其中平均表型是最显着的影响。这些结果表明，产生表型平均值变化的相同发育机制也产生方差变化。
The semi‐dominantBrmutation affects presphenoid growth, producing the facial retrognathism and globular neurocranial vault that characterize heterozygotes. We analysed the impact of this mutation on skull shape, comparing heterozygotes to wildtype mice, to determine if the effects are skull‐wide or confined to the sphenoid region targeted by the mutation. In addition, we examined patterns of variability of shape for the skull as a whole and for three regions (basicranium, face and neurocranium). We found that theBrmice differed significantly from wildtype mice in skull shape in all three regions as well as in the shape of the skull as a whole. However, the significant increases in variance and fluctuating asymmetry were found only in the basicranium of mutant mice. These results suggest that the mutation has a significant effect on the underlying developmental architecture of the skull, which produces an increase in phenotypic variability that is localized to the anatomical region in which the mean phenotype is most dramatically affected. These results suggest that the same developmental mechanisms that produce the change in phenotypic mean also produce the change in variance.