Inflammatory response in the acute phase of deep vein thrombosis
Inflammatory response in the acute phase of deep vein thrombosis
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DOI：
10.1067/mva.2002.121746
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发表时间：
2002-04-01
影响因子：
4.3
通讯作者：
Wollersheim, H
中科院分区：
文献类型：
--
作者：
Roumen-Klappe, EM;den Heijer, M;Wollersheim, H
目的：深静脉血栓形成（DVT）是一种多因素疾病。最近，炎症被认为是 DVT 的危险因素。问题是炎症是静脉血栓形成的原因还是血栓形成过程的结果。方法。我们以白细胞介素 6、白细胞介素 8 和 C 反应蛋白 (CRP) 作为炎症标志物研究了 DVT 急性期的炎症反应。在入院当天（第 0 天）测量了 40 名经静脉造影证实的急性 DVT 患者和 33 名临床怀疑 DVT 但静脉造影结果呈阴性的患者（对照）的血浆浓度。在 DVT 患者中，还在随后的五天内检查了炎症标志物。结果。 On day 0, the median concentrations in plasma of interleukin-6, interleukin-8, and CRP were 15.0 pg/mL (range,
Objective: Deep vein thrombosis (DVT) is a multifactorial disease. Recently, inflammation has been suggested as a risk factor for DVT. The question is whether inflammation is a cause of venous thrombosis or rather a result of the thrombotic process.Methods. We studied the inflammatory response in the acute phase of DVT with interleukin-6, interleukin-8, and C-reactive protein (CRP) as inflammatory markers. Plasma concentrations were measured on the day of admission (day 0) in 40 patients with acute DVT confirmed with phlebography and in 33 patients with clinical suspicion of DVT but negative phlebography results (controls). In patients with DVT, inflammatory markers were also examined on five subsequent days.Results. On day 0, the median concentrations in plasma of interleukin-6, interleukin-8, and CRP were 15.0 pg/mL (range,