Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
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DOI：
10.1210/jc.2004-2364
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发表时间：
2005-06-01
影响因子：
5.8
通讯作者：
de Papp, AE
中科院分区：
文献类型：
--
作者：
Holick, MF;Siris, ES;de Papp, AE
目的：评估接受治疗或预防骨质疏松症的绝经后北美妇女的血清 25-羟基维生素 D [ 25(OH)D] 浓度以及与维生素 D 不足相关的因素。方法：在 2003 年 11 月至 2004 年 3 月期间，采集了 1536 名社区居住妇女的血清 25(OH)D 和 PTH。使用多变量逻辑回归来评估骨质疏松症的危险因素。 次优 ( < 30 ng/ml) 25( OH) D. 结果：92% 的研究对象是白人，平均年龄为 71 岁。 35% 的人居住在北纬 42 度或以上，24% 的人居住在北纬 35 度以下。血清 25(OH)D 平均值 (SD) 为 30.4 (13.2) ng/ml：18% 的血清 25(OH)D 低于 20 ng/ml； 36% 的人低于 25 ng/ml； 52% 的人低于 30 ng/ml。服用少于 400 IU/天或更多维生素 D 的受试者中 25( OH) D 不理想的患病率显着较高。血清 PTH 浓度与 25( OH) D 之间存在显着负相关。与维生素 D 不足相关的危险因素包括年龄、种族、体重指数、已知影响维生素 D 代谢的药物、维生素 D 补充剂、锻炼、教育和医生咨询 维生素 D。结论：超过一半接受骨质疏松症治疗或预防治疗的北美女性维生素 D 不足，这强调需要改进医生和公众教育，以优化该人群的维生素 D 状况。
Purpose: To evaluate serum 25-hydroxyvitamin D [ 25( OH) D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis.Methods: Serum 25( OH) D and PTH were obtained in 1536 community-dwelling women between November 2003 and March 2004. Multivariate logistic regression was used to assess risk factors for suboptimal ( < 30 ng/ml) 25( OH) D.Results: Ninety-two percent of study subjects were Caucasian, with a mean age of 71 yr. Thirty-five percent resided at or above latitude 42 degrees north, and 24% resided less than 35 degrees north. Mean (SD) serum 25( OH) D was 30.4 (13.2) ng/ml: serum 25( OH) D was less than 20 ng/ml in 18%; less than 25 ng/ml in 36%; and less than 30 ng/ml in 52%. Prevalence of suboptimal 25( OH) D was significantly higher in subjects who took less than 400 vs. 400 IU/d or more vitamin D. There was a significant negative correlation between serum PTH concentrations and 25( OH) D. Risk factors related to vitamin D inadequacy included age, race, body mass index, medications known to affect vitamin D metabolism, vitamin D supplementation, exercise, education, and physician counseling regarding vitamin D.Conclusions: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population.