Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects
Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects
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DOI：
10.1016/s0165-1781(96)03052-1
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发表时间：
1997-03-24
影响因子：
11.3
通讯作者：
Bond, AJ
中科院分区：
文献类型：
--
作者：
Cleare, AJ;Bond, AJ
许多研究调查了暴力或人格障碍人群中血清素功能与攻击性之间的可能联系，但很少有研究关注健康受试者。在这项研究中，我们给35名健康受试者服用了30毫克特异性5-羟色胺释放剂d -芬氟拉明，并对他们进行了敌意和攻击性问卷调查。催乳素和皮质醇反应作为中枢5-HT功能的指标。在男性中，5-HT介导的皮质醇反应与Buss-Durkee敌意量表总分和攻击因子之间存在显著的负相关。在女性受试者或使用催乳素反应中没有这种关系。基础皮质醇水平与催乳素和皮质醇反应之间也存在反比关系，但基础皮质醇水平与积极措施之间没有关系。这些结果为健康男性中中枢血清素功能与攻击性/敌意之间存在反比关系提供了一些支持，类似于先前对暴力或高度攻击性人群的研究。(C) 1997爱思唯尔科学爱尔兰有限公司
Much research has investigated possible links between serotonergic function and aggression in violent or personality disordered populations, but few studies have looked at healthy subjects. In this study we administered 30 mg of the specific 5-HT releasing agent D-fenfluramine to 35 healthy subjects, along with questionnaire measures of hostility and aggression. Prolactin and cortisol responses were used as indices of central 5-HT function. In males, there were significant inverse correlations between 5-HT mediated cortisol responses and both the Buss-Durkee Hostility Inventory total score and the aggression factor. There were no such relations in female subjects or using prolactin responses. There was also an inverse relation between basal cortisol levels and both prolactin and cortisol responses, but no relation between basal cortisol levels and aggressive measures. These results provide some support for the existence of an inverse relationship between central serotonin function and aggression/hostility in healthy males, similar to that seen in previous studies using violent or highly aggressive populations. (C) 1997 Elsevier Science Ireland Ltd.