Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: A report from the NHLBI-sponsored WISE study
Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: A report from the NHLBI-sponsored WISE study
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DOI：
10.1016/s0735-1097(02)02763-8
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发表时间：
2003-02-05
影响因子：
24
通讯作者：
Sopko, G
中科院分区：
文献类型：
--
作者：
Merz, CNB;Johnson, BD;Sopko, G
目的探讨绝经前妇女下丘脑源性低雌激素血症及其与冠状动脉造影术冠状动脉疾病(CAD)的关系。灵长类动物数据表明，绝经前冠心病是由心理社会应激引起的排卵周期中枢紊乱和导致的雌激素减少所决定的。方法我们利用核心实验室对95名有冠状动脉危险因素的绝经前妇女的血液生殖激素水平和血管造影CAD进行了评估，这些妇女参加了国家心肺血液研究所赞助的妇女缺血综合征评估，并接受了冠状动脉造影术以评估可疑的缺血。结果有血管造影CAD的绝经前妇女(n=13)的雌二醇、生物可用雌二醇和卵泡刺激素(FSH)显著低于没有血管造影CAD的妇女(n=82)(P均<0.05)。起源于下丘脑的低雌激素血症，定义为雌二醇
OBJECTIVES We sought to evaluate hypoestrogenemia of hypothalamic origin and its association with angiographic coronary artery disease (CAD) in premenopausal women.BACKGROUND Coronary artery disease in premenopausal women appears to have a particularly poor prognosis. Primate animal data suggest that premenopausal CAD is strongly determined by psychosocial stress-induced central disruption of ovulatory cycling and resulting hypoestrogenemia.METHODS We assessed reproductive hormone blood levels and angiographic CAD using core laboratories in 95 premenopausal women with coronary risk factors who were enrolled in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation and were undergoing coronary angiography for evaluation for suspected ischemia.RESULTS Premenopausal women with angiographic CAD (n = 13) had significantly lower estradiol, bioavailable estradiol, and follicle-stimulating hormone (FSH) (all p < 0.05) than women without angiographic CAD (n = 82), even after controlling for age. Hypoestrogenemia of hypothalamic origin, defined as estradiol