Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process Clonal analysis identifies shared origin of all pigment cell types
Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process Clonal analysis identifies shared origin of all pigment cell types
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DOI：
10.1002/bies.201600234
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发表时间：
2017-03-01
期刊：
影响因子：
4
通讯作者：
Yates, Christian A.
中科院分区：
文献类型：
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作者：
Kelsh, Robert N.;Sosa, Karen C.;Yates, Christian A.
皮肤色素图案形成是图案形成的范例。在斑马鱼中，成年体条纹是由三种不同的色素细胞类型协调重排产生的，黑色黑素细胞，闪亮的虹膜细胞和黄色的黄色素细胞。黑素细胞和虹膜细胞的干细胞起源已被提出，尽管这些干细胞的潜能仍不清楚。然而，Xanthophores，似乎主要来自胚胎xanthophores的增殖。现在，Singh等人的数据表明，这三种细胞类型都源自共享的干细胞，并且这些细胞也产生外周神经细胞类型。此外，克隆组合物最好通过产生个体细胞类型的渐进命运限制模型来解释。与背根神经节相关的成体色素干细胞的数量仍然很低，但在幼虫发育至变态期间，祖细胞数量显着增加，可能是通过在脊神经上产生部分限制的祖细胞。
Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.