Ovarian Cancer Risk Factors in African-American and White Women
Ovarian Cancer Risk Factors in African-American and White Women
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DOI：
10.1093/aje/kwp176
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发表时间：
2009-09-01
影响因子：
5
通讯作者：
Schildkraut, Joellen M.
中科院分区：
文献类型：
--
作者：
Moorman, Patricia G.;Palmieri, Rachel T.;Schildkraut, Joellen M.
卵巢癌是最致命的妇科恶性肿瘤在非洲裔美国人和白色妇女。虽然许多卵巢癌危险因素的患病率在非洲裔美国人和白人之间存在显着差异，但很少有研究表明风险因素的相对贡献在种族/族裔群体之间可能存在差异。使用来自北卡罗来纳州病例对照研究（1999-2008）的数据，作者进行了非条件logistic回归分析，以计算非洲裔美国人（143例，189例对照）和白色（943例，868例对照）女性卵巢癌风险因素的比值比和95%置信区间，并测试种族/民族的相互作用。他们还计算了每个种族/民族中可改变因素妊娠、口服避孕药使用、输卵管结扎和体重指数的可归因分数。许多风险因素在种族/民族群体中表现出相似的关系，但输卵管结扎和乳腺癌或卵巢癌家族史在非裔美国人中表现出更强的关联。只有白色女性初潮年龄较小与风险相关。非裔美国人与输卵管结扎、口服避孕药使用和肥胖相关的归因分数明显较高。卵巢癌危险因素的相对重要性可能与非洲裔美国妇女不同，但结论受到样本量小的限制。有一个明确的需要进一步研究的病因因素卵巢癌的非洲裔美国妇女。
Ovarian cancer is the most lethal gynecologic malignancy in both African-American and white women. Although prevalences of many ovarian cancer risk factors differ markedly between African Americans and whites, there has been little research on how the relative contributions of risk factors may vary between racial/ethnic groups. Using data from a North Carolina case-control study (1999-2008), the authors conducted unconditional logistic regression analyses to calculate odds ratios and 95% confidence intervals for ovarian cancer risk factors in African-American (143 cases, 189 controls) and white (943 cases, 868 controls) women and to test for interactions by race/ethnicity. They also calculated attributable fractions within each racial/ethnic group for the modifiable factors of pregnancy, oral contraceptive use, tubal ligation, and body mass index. Many risk factors showed similar relations across racial/ethnic groups, but tubal ligation and family history of breast or ovarian cancer showed stronger associations among African Americans. Younger age at menarche was associated with risk only in white women. Attributable fractions associated with tubal ligation, oral contraceptive use, and obesity were markedly higher for African Americans. The relative importance of ovarian cancer risk factors may differ for African-American women, but conclusions were limited by the small sample. There is a clear need for further research on etiologic factors for ovarian cancer in African-American women.