Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells.
Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells.
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DOI：
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发表时间：
1975-09
影响因子：
4.4
通讯作者：
H. Kaplan;J. Streilein;T. Stevens
中科院分区：
文献类型：
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作者：
H. Kaplan;J. Streilein;T. Stevens
在近交系大鼠中研究了眼前房对同种异体供体组织的免疫豁免机制。同种异体淋巴细胞接种到前房表明，虽然该网站缺乏淋巴引流，免疫反射弧的传入分支是完整的，因为收件人可以识别和安装一个特定的免疫反应。此外，当系统性诱导时，宿主免疫能够在前房内表达自身，表明反射弧的传出支也是完整的。因此，有人建议，独特的免疫功能的前房可能会导致从专性静脉内提交的移植物抗原的主机的全身免疫装置，一条路线，偏见的耐受性和/或增强，而不是细胞介导的，组织破坏性免疫的方向主机的反应。
The mechanism by which the anterior chamber of the eye extends immunologic privilege to allogeneic donor tissues has been studied in inbred rats. Inoculation of allogeneic lymphoid cells into the anterior chamber demonstrated that although the site lacks a lymphatic drainage, the afferent limb of the immunologic reflex arc is intact because the recipient can recognize and mount a specific immune response. In addition, host immunity was able to express itself within the anterior chamber when induced systemically, indicating that the efferent limb of the reflex arc is also intact. Therefore, it is suggested that the unique immunologic features of the anterior chamber may result from the obligate intravenous presentation of graft antigen to the host's systemic immunologic apparatus, a route that prejudices the host's response in the direction of tolerance and/or enhancement rather than cell-mediated, tissue destructive immunity.