Genistein as an anti-inflammatory agent
Genistein as an anti-inflammatory agent
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DOI：
10.1007/s00011-003-1182-8
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发表时间：
2003-08-01
影响因子：
6.7
通讯作者：
Tarkowski, A
中科院分区：
文献类型：
--
作者：
Verdrengh, M;Jonsson, IM;Tarkowski, A
目的和设计：本研究的目的是研究异黄酮染料木素对体内细胞介导的反应的影响。此外，我们还研究了金雀异黄素对胶原性关节炎(CIA)小鼠的影响。方法：观察金雀异黄素对小鼠对恶唑酮的迟发型超敏反应(DTH)和对橄榄油的炎症反应。结果：与对照组相比，染料木素处理组小鼠对恶唑酮的迟发型超敏反应和粒细胞介导的反应均受到明显抑制。此外，染料木素治疗导致恶唑酮特异性抗体水平下降。组织学上，暴露于染料木素和II型胶原免疫的小鼠表现出较低的炎症和关节破坏程度。结论：金雀异黄素对粒细胞、单核细胞和淋巴细胞均有明显的抗炎作用。
Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice.Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined.Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice.Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.