TIME-COURSE FOR EXERCISE-INDUCED ALTERATIONS IN INSULIN ACTION AND GLUCOSE-TOLERANCE IN MIDDLE-AGED PEOPLE
TIME-COURSE FOR EXERCISE-INDUCED ALTERATIONS IN INSULIN ACTION AND GLUCOSE-TOLERANCE IN MIDDLE-AGED PEOPLE
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DOI：
10.1152/jappl.1995.78.1.17
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发表时间：
1995-01-01
影响因子：
3.3
通讯作者：
RIDDLE, MS
中科院分区：
文献类型：
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作者：
KING, DS;BALDUS, PJ;RIDDLE, MS
本研究的目的是1)研究运动后即刻的糖耐量和胰岛素作用；2)确定运动后12-16小时观察到的改善的血糖稳态机制持续多久。9名(7名男性，2名女性)中年(51+/-3岁)受试者以73+/-2%的峰值氧摄取量进行45min的运动，持续5天，然后进行7天的不活动。运动后即刻、运动后第1、3、5、7天分别进行口服葡萄糖耐量试验(OGTT；75g，相当于30min)。血糖曲线下增量面积(355±/-82 mm min)明显高于第1天(136±57 mm·min；P<0.05)和第3天(173±62 mm·min；P&t；0.05)。血糖面积在第5天(213±80 mm·min)和第7天(225±84 mm·min)明显高于第1天和第3天(P<；0.05)。胰岛素增量面积IPE(3,729+/-1,104亩·ml(-1)·min)比第1天(2,603+/-635亩·ml(-1)min；P<；0.05)高43%，比第3天(2,240+/-517亩·ml(-1).min；P<；0.05)高66%。停用5天后胰岛素面积增加到3,616+/-617亩·ml(-1)·min(P<；0.05)。另外48小时的不活动并没有导致血浆胰岛素反应的进一步增加。治疗前血浆游离脂肪酸浓度(0.79±0.07 mM)明显高于治疗第1天(0.28±0.03 mM；P<；0.001)，至治疗结束时仍高于治疗前(0.07±0.02vs.0.03+/-0.01 mM；P<；0.001)。这些数据显示，运动后立即出现夸大的胰岛素反应和明显的胰岛素作用障碍。这种短暂的胰岛素抵抗与血浆游离脂肪酸浓度升高有关，在24小时内被胰岛素作用增强和胰岛素反应减弱所取代。运动后胰岛素作用和糖耐量的改善持续3天，而不是5天。
The purposes of this study were 1) to investigate glucose tolerance and insulin action immediately after exercise and 2) to determine how long the improved glucose homeostatic mechanisms observed 12-16 h after exercise persist. Nine (seven men, two women) moderately trained middle-aged (51 +/- 3 yr) subjects performed 45 min of exercise at 73 +/- 2% of peak O-2 uptake for 5 days, followed by 7 days of inactivity. Oral glucose tolerance tests (OGTT; 75 g) were performed immediately postexercise (IPE; similar to 30 min) after the final exercise bout and 1, 3, 5, and 7 days after exercise. The incremental area under the plasma glucose curve was markedly higher IPE (355 +/- 82 mM min) compared with those on days 1 (136 +/- 57 mM.min; P < 0.05) and 3 (173 +/- 62 mM.min; P < 0.05). The glucose area was significantly higher on days 5 (213 +/- 80 mM.min) and 7 (225 +/- 84 mM.min) compared with those on days 1 and 3 (P < 0.05). The incremental insulin area IPE (3,729 +/- 1,104 mu U.ml(-1).min) was 43% higher compared with that on day 1 (2,603 +/- 635 mu U.ml(-1) min; P < 0.05) and 66% higher compared with that on day 3 (2,240 +/- 517 mu U.ml(-1).min; P < 0.05). The insulin area increased to 3,616 +/- 617 mu U.ml(-1).min after 5 days of inactivity (P < 0.05). An additional 48 h of inactivity did not result in any further increase in the plasma insulin response. Plasma free fatty acid concentrations were markedly higher before the OGTT performed IPE (0.79 +/- 0.07 mM) compared with those on day 1 (0.28 +/- 0.03 mM; P < 0.001) and remained higher (0.07 +/- 0.02 vs. 0.03 +/- 0.01 mM; P < 0.001) IPE at the conclusion of the OGTT. These data show an exaggerated insulin response and a marked impairment of insulin action immediately after exercise. This transient insulin resistance, which is associated with elevated plasma free fatty acid concentrations, is replaced within 24 h by enhanced insulin action and a reduced insulin response. The improved insulin action and glucose tolerance after exercise persist for 3 days but not for 5 days.