The Roles of Post-Translational Modifications on mTOR Signaling.
The Roles of Post-Translational Modifications on mTOR Signaling.
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翻译：翻译后修饰在mTOR信号传导中的作用
DOI：
10.3390/ijms22041784
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发表时间：
2021-02-11
影响因子：
5.6
通讯作者：
Gan W
中科院分区：
文献类型：
--
作者：
Yin S;Liu L;Gan W
雷帕霉素的机制靶点（mTOR）是通过整合各种环境输入，包括生长因子、营养物质和能量等，来调节细胞生长、增殖和代谢的主要调控因子。mTOR信号传导已被证明可以控制几乎所有的基本细胞过程，如核苷酸、蛋白质和脂质合成、自噬和凋亡。在过去的15年里，绘制mTOR通路网络极大地提高了我们对其上游和下游信号传导的理解。mTOR通路的失调通常与多种人类疾病有关，如癌症、代谢性疾病、心血管和神经退行性疾病。除了遗传改变外，mTOR组分的翻译后修饰（ptm）异常是许多病理中mTOR信号异常的主要原因。在这篇综述中，我们总结了目前对ptm介导的mTOR信号调节的理解，并更新了针对mTOR途径和ptm相关酶治疗人类疾病的进展。
The mechanistic target of rapamycin (mTOR) is a master regulator of cell growth, proliferation, and metabolism by integrating various environmental inputs including growth factors, nutrients, and energy, among others. mTOR signaling has been demonstrated to control almost all fundamental cellular processes, such as nucleotide, protein and lipid synthesis, autophagy, and apoptosis. Over the past fifteen years, mapping the network of the mTOR pathway has dramatically advanced our understanding of its upstream and downstream signaling. Dysregulation of the mTOR pathway is frequently associated with a variety of human diseases, such as cancers, metabolic diseases, and cardiovascular and neurodegenerative disorders. Besides genetic alterations, aberrancies in post-translational modifications (PTMs) of the mTOR components are the major causes of the aberrant mTOR signaling in a number of pathologies. In this review, we summarize current understanding of PTMs-mediated regulation of mTOR signaling, and also update the progress on targeting the mTOR pathway and PTM-related enzymes for treatment of human diseases.
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影响因子：
5.4
作者：
Ahearn I;Zhou M;Philips MR
通讯作者：
Philips MR
DOI：
10.1038/s41436-018-0060-2
发表时间：
2019-03
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Baldassari S;Picard F;Verbeek NE;van Kempen M;Brilstra EH;Lesca G;Conti V;Guerrini R;Bisulli F;Licchetta L;Pippucci T;Tinuper P;Hirsch E;de Saint Martin A;Chelly J;Rudolf G;Chipaux M;Ferrand-Sorbets S;Dorfmüller G;Sisodiya S;Balestrini S;Schoeler N;Hernandez-Hernandez L;Krithika S;Oegema R;Hagebeuk E;Gunning B;Deckers C;Berghuis B;Wegner I;Niks E;Jansen FE;Braun K;de Jong D;Rubboli G;Talvik I;Sander V;Uldall P;Jacquemont ML;Nava C;Leguern E;Julia S;Gambardella A;d'Orsi G;Crichiutti G;Faivre L;Darmency V;Benova B;Krsek P;Biraben A;Lebre AS;Jennesson M;Sattar S;Marchal C;Nordli DR Jr;Lindstrom K;Striano P;Lomax LB;Kiss C;Bartolomei F;Lepine AF;Schoonjans AS;Stouffs K;Jansen A;Panagiotakaki E;Ricard-Mousnier B;Thevenon J;de Bellescize J;Catenoix H;Dorn T;Zenker M;Müller-Schlüter K;Brandt C;Krey I;Polster T;Wolff M;Balci M;Rostasy K;Achaz G;Zacher P;Becher T;Cloppenborg T;Yuskaitis CJ;Weckhuysen S;Poduri A;Lemke JR;Møller RS;Baulac S
通讯作者：
Baulac S
影响因子：
14.5
作者：
Cai, Zhen;Moten, Asad;Peng, Danni;Hsu, Che-Chia;Pan, Bo-Syong;Manne, Rajeshkumar;Li, Hong-yu;Lin, Hui-Kuan
通讯作者：
Lin, Hui-Kuan
DOI：
10.1073/pnas.0409143102
发表时间：
2005-01-18
影响因子：
11.1
作者：
Ballif, BA;Roux, PP;Gygi, SP
通讯作者：
Gygi, SP
影响因子：
4.5
作者：
Beaudoin M;Goyette P;Boucher G;Lo KS;Rivas MA;Stevens C;Alikashani A;Ladouceur M;Ellinghaus D;Törkvist L;Goel G;Lagacé C;Annese V;Bitton A;Begun J;Brant SR;Bresso F;Cho JH;Duerr RH;Halfvarson J;McGovern DP;Radford-Smith G;Schreiber S;Schumm PL;Sharma Y;Silverberg MS;Weersma RK;Quebec IBD Genetics Consortium;NIDDK IBD Genetics Consortium;International IBD Genetics Consortium;D'Amato M;Vermeire S;Franke A;Lettre G;Xavier RJ;Daly MJ;Rioux JD
通讯作者：
Rioux JD