Stable and unstable angina: Identifying novel markers on circulating leukocytes
Stable and unstable angina: Identifying novel markers on circulating leukocytes
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DOI：
10.1002/prca.200780090
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
dos Remedios, Cristobal
中科院分区：
文献类型：
--
作者：
Brown, Angus;Lattimore, Jo-Dee;dos Remedios, Cristobal
目前还没有基于血液的测试可以快速、客观地区分由心肌需氧量增加引发的胸痛（稳定型心绞痛（SAP））和由冠状动脉血流量减少引发的胸痛（不稳定型心绞痛（UAP））。由于白细胞在冠状动脉疾病 (CAD) 的进展中发挥着积极作用，我们假设它们可以提供 SAP 和 UAP 的新标记物。在这里，我们使用 82 簇分化 (CD) 抗体（加上对照）的微阵列选择性地固定外周血单核细胞。我们发现 CAD 患者的白细胞固定模式与健康捐献者显着不同。在 CAD 组中，15 名 SAP 患者表现出显着的 (p
There is currently no blood-based test that can rapidly and objectively distinguish between chest pain which is initiated by increased myocardial oxygen demand (stable angina pectoris (SAP)) and chest pain initiated due to decreased coronary blood flow (unstable angina pectoris (UAP)). Since leukocytes play an active role in the progression of coronary artery disease (CAD), we hypothesize these can provide novel markers of SAP and UAP. Here we use a microarray of 82 cluster of differentiation (CD) antibodies (plus controls) to selectively immobilize peripheral blood mononuclear cells. We find that the pattern of leukocyte immobilization from patients with CAD significantly differs from healthy donors. Within the CAD group, 15 SAP patients exhibited significant (p