Mesenchymal stem cells: Potential role in corneal wound repair and transplantation.
Mesenchymal stem cells: Potential role in corneal wound repair and transplantation.
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DOI：
10.4252/wjsc.v6.i3.296
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发表时间：
2014-07-26
影响因子：
4.1
通讯作者：
Zhao, Shao-Zhen
中科院分区：
文献类型：
--
作者：
Li, Fei;Zhao, Shao-Zhen
角膜疾病是世界上致盲的主要原因。虽然角膜疾病的治疗已经取得了很大的进展，但严重角膜损伤后的伤口愈合和角膜移植后的免疫抑制治疗仍然存在问题。间充质干细胞（Mesenchymal stem cells，MSCs）是一种来源于骨髓或其它成人组织的间充质干细胞，在体内和体外均可分化为骨细胞、脂肪细胞和软骨细胞等多种类型的间充质细胞。这些细胞可以在特定条件下进一步分化成特定的细胞类型。MSC迁移到损伤部位，并通过分泌抗炎和生长因子促进伤口愈合。此外，MSC与先天性和获得性免疫细胞相互作用，并通过其强大的旁分泌功能调节免疫应答。在过去的十年中，MSC由于其有益的特性和有前途的治疗前景而引起了相当大的关注。此外，MSC已被应用于与伤口愈合、自身免疫性疾病和器官移植相关的各种研究。本文就骨髓间充质干细胞对角膜组织的保护作用及其在角膜创伤愈合和角膜移植中的作用机制作一综述。
Corneal diseases are a major cause of blindness in the world. Although great progress has been achieved in the treatment of corneal diseases, wound healing after severe corneal damage and immunosuppressive therapy after corneal transplantation remain problematic. Mesenchymal stem cells (MSCs) derived from bone marrow or other adult tissues can differentiate into various types of mesenchymal lineages, such as osteocytes, adipocytes, and chondrocytes, both in vivo and in vitro. These cells can further differentiate into specific cell types under specific conditions. MSCs migrate to injury sites and promote wound healing by secreting anti-inflammatory and growth factors. In addition, MSCs interact with innate and acquired immune cells and modulate the immune response through their powerful paracrine function. Over the last decade, MSCs have drawn considerable attention because of their beneficial properties and promising therapeutic prospective. Furthermore, MSCs have been applied to various studies related to wound healing, autoimmune diseases, and organ transplantation. This review discusses the potential functions of MSCs in protecting corneal tissue and their possible mechanisms in corneal wound healing and corneal transplantation.