Protective Effects of Platycodi radix on Alcohol-Induced Fatty Liver

Protective Effects of Platycodi radix on Alcohol-Induced Fatty Liver
复制标题

DOI：
10.1271/bbb.60523
复制
发表时间：
2007-06
期刊：
Bioscience, Biotechnology, and Biochemistry
影响因子：
--
通讯作者：
H. Kim;Dong-Sub Kim;H. Cho
H. Kim;Dong-Sub Kim;H. Cho
中科院分区：
其他
文献类型：
--
作者：
H. Kim;Dong-Sub Kim;H. Cho

文献摘要

被引文献

相似文献

研究桔梗根对大鼠酒精性脂肪肝的保护作用及其可能的机制。给予PR可显著抑制酒精所致的血清和肝脂升高。此外，PR治疗可使酒精所致大鼠肝脏脂肪酸结合蛋白(L-FABP)的表达和细胞色素P4502E1活性恢复正常。这些结果提示，PR对细胞色素P4502E_2的抑制和L-FABP的调节在酒精性肝保护中起重要作用。
The protective effects of Platycodi radix (PR), the root of Platycodon grandiflorum A. DC, on alcohol-induced fatty liver and possible mechanisms involved in this protection were investigated in rats. Administration of PR significantly prevented alcohol-induced elevation of serum and liver lipids. Furthermore, PR treatment normalized hepatic liver fatty acid binding protein (L-FABP) expression and cytochrome P450 2E1 (CYP2E1) activity in alcohol-treated rats. These results suggest that inhibition of CYP2E1 and regulation of L-FABP by PR play an important role in alcohol-induced hepatoprotection.