CD4(+)T cell specific B7-H1 selectively inhibits proliferation of naïve T cells and Th17 differentiation in experimental autoimmune encephalomyelitis.
CD4(+)T cell specific B7-H1 selectively inhibits proliferation of naïve T cells and Th17 differentiation in experimental autoimmune encephalomyelitis.
复制标题
CD4 T 细胞特异性 B7-H1 选择性抑制实验性自身免疫性脑脊髓炎中幼稚 T 细胞的增殖和 Th17 分化
DOI：
10.18632/oncotarget.21357
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发表时间：
2017-10-27
期刊：
影响因子：
--
通讯作者：
Wen WH
中科院分区：
文献类型：
--
作者：
Shi SJ;Ding ML;Wang LJ;Wu JH;Han DH;Zheng GX;Guo ZY;Xi WJ;Qin WJ;Yang AG;Wen WH
目前广泛认为，产生白细胞介素17的辅助性T细胞（Th 17）在多发性硬化的发病机制中起关键作用。实验性自身免疫性脑脊髓炎（Experimental Autoimmune encephalomyelitis，EAE）患者脾细胞、脑和脊髓单个核细胞中CD 4 +T细胞特异性共抑制分子B7-homologue 1（B7-H1）的表达与Th 1和Th 17细胞的生成及疾病严重程度呈正相关。此外，与B7-H1野生型小鼠相比，B7-H1转基因小鼠出现更轻的EAE症状和更少的Th 17细胞。我们还发现从B7-H1转基因小鼠中分离的幼稚CD 4 + CD 62 +T细胞的增殖受到抑制。B7-H1转基因小鼠的幼稚T细胞在Th 17极化条件下产生的Th 17细胞少于WT小鼠，但Th 1、Th 2和诱导性Treg分化在B7-H1转基因小鼠和WT小鼠中相似。结论：CD 4 +T细胞特异性B7-H1对幼稚T细胞增殖、Th 17分化及多发性硬化的发病具有选择性抑制作用。
It is widely acknowledged that interleukin 17-producing T helper (Th17) cells are critically participant in the pathogenesis of multiple sclerosis. In the current study, we identified that the expression of CD4+T cells specific co-inhibitory molecule B7-homologue 1(B7-H1) in spleenocytes and mononuclear cells isolated from brains and spinal cord were positive correlated with Th1 and Th17 cells generation and disease severity in experimental autoimmune encephalomyelitis (EAE). Furthermore, B7-H1 transgenic mice developed milder EAE symptoms and fewer Th17 cells than B7-H1 wild type mice. We also found the proliferation of naïve CD4+CD62+T cells isolated from B7-H1 transgenic mice was inhibited. And naïve T cells isolated from B7-H1 transgenic mice produced fewer Th17 cells than WT mice in Th17-polarizing conditions, but the Th1, Th2, and inducible Treg differentiation were the similar in naïve T cells isolated from B7-H1 transgenic mice and WT mice. In conclusion, our study show CD4+T cells specific B7-H1 is a slective inhibitor in proliferation of naïve T cells, Th17 differentiation and pathogenesis of multiple sclerosis.
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影响因子：
30.5
作者：
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