EFFECTS OF SLEEP-DEPRIVATION ON SLEEPINESS, SLEEP INTENSITY, AND SUBSEQUENT SLEEP IN THE RAT
EFFECTS OF SLEEP-DEPRIVATION ON SLEEPINESS, SLEEP INTENSITY, AND SUBSEQUENT SLEEP IN THE RAT
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DOI：
10.1093/sleep/1.4.369
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发表时间：
1979-01-01
期刊：
影响因子：
5.6
通讯作者：
RECHTSCHAFFEN, A
中科院分区：
文献类型：
--
作者：
FRIEDMAN, L;BERGMANN, BM;RECHTSCHAFFEN, A
在大鼠中研究了 24 小时睡眠剥夺对皮质脑电图和腹侧海马脑电图记录、腹侧海马尖峰率、睡眠阶段百分比和回合长度测量的影响。两组仅在水车法剥夺期间被迫行走的速度和距离有所不同，连续记录（每天 23 小时）1 个基线、1 个剥夺日和 2 个恢复日。在剥夺期间，微睡眠、海马尖峰率增加以及脑电图记录振幅增加都表明睡眠过程受到干扰。尽管如此，没有证据支持这些动物并未被严重剥夺睡眠的观点。尽管一组在剥夺期间行走的距离是另一组的三倍，但两组的恢复数据没有发现重要差异。这支持了这样的观点：在大量睡眠不足的情况下，运动量的变化和能量消耗可能对睡眠指标影响不大。在恢复过程中，海马尖峰率和发作长度的增加，以及脑电图振幅的增加，都被解释为睡眠“强度”的增加。高振幅 NREM 睡眠首先反弹，随后矛盾睡眠和低振幅 NREM 睡眠均出现反弹。将该模式与之前报道的人类、猫和大鼠的模式进行了比较。最后，从“睡眠抑制”和伺服机制理论的角度讨论了一些指标在最初反弹后下降到基线水平以下的趋势。
The effects of 24 hr of sleep deprivation on cortical EEG and ventral hippocampus EEG recordings, ventral hippocampus spike rates, sleep stage percentages, and bout length measures were studied in rats. Two groups, differing only in the rate and distance they were forced to walk during deprivation by the water wheel method, were recorded continuously (23 hr per day) for one baseline, one deprivation, and two recovery days. During deprivation, microsleeps, increased hippocampal spike rates, and increased amplitude of the EEG recordings all suggested the intrusion of sleep processes. Nonetheless, there was no evidence to support the idea that these animals were not substantially deprived of sleep. No important differences were found in the recovery data of the two groups, even though one group walked three times as far as the other during deprivation. This supports the idea that, in conjunction with large amounts of sleep deprivation, changes in exercise and energy depletion may have little effect on sleep measures. During recovery, increased hippocampal spike rates and bout lengths, as well as increases in EEG amplitude, were interpreted in terms of increased sleep “intensity.” High amplitude NREM sleep rebounded firs't, followed by rebounds in both paradoxical sleep and low amplitude NREM sleep. This pattern was compared to patterns previously reported for humans, cats, and rats. Finally, the tendency for some measures to fallbelowtheir baseline levels after an initial rebound was discussed in terms of “sleep inhibition” and servomechanism theory.