Vav1 in hematologic neoplasms, a mini review.
Vav1 in hematologic neoplasms, a mini review.
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发表时间：
2012
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通讯作者：
M. Oberley;Deng-shun Wang;David T Yang
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文献类型：
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作者：
M. Oberley;Deng-shun Wang;David T Yang
蛋白质的Vav家族是鸟嘌呤核苷酸交换因子，其已被证明在几种类型的人类癌症中失调。已经鉴定了Vav家族的三个成员，它们是Dbl结构域超家族的成员，并且对Rho/Rac GTP酶具有特异性。Vav家族在正常的血液系统发育和稳态中起着重要的作用，Vav 1在很大程度上局限于血液系统。虽然Vav 1最初被鉴定为原癌基因，但最近的几项研究表明，Vav家族缺失导致小鼠T细胞恶性肿瘤的发展。此外，Vav 1已被证明在ATRA介导的早幼粒细胞白血病细胞分化中发挥作用。在这篇简要的综述中，我们对Vav 1的基因结构和正常功能，以及Vav 1在血液系统和其他恶性肿瘤的发展中可能发挥的作用进行了综述。
The Vav family of proteins are guanine nucleotide exchange factors which have been shown to be deregulated in several types of human cancer. There are three members of the Vav family that have been identified which are members of the Dbl domain superfamily and have specificity towards Rho/Rac GTPases. The Vav family plays an important role in normal hematologic system development and homeostasis, and Vav1 is largely restricted to the hematologic system. While Vav1 was originally identified as a proto-oncogene, several recent studies have shown that Vav family deletion leads to the development of T-cell malignancies in mice. In addition, Vav1 has been shown to play a role in the ATRA-mediated differentiation of promyelocytic leukemia cells. In this concise review, the gene structure and normal function of Vav1, as well as a possible role for Vav1 in the development of hematologic and other malignancies is reviewed.