Serum levels of angiogenesis-related factors in patients with psoriasis.
Serum levels of angiogenesis-related factors in patients with psoriasis.
复制标题
银屑病患者血管生成相关因子的血清水平。
DOI：
10.1111/1346-8138.16588
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tada Y
中科院分区：
文献类型：
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作者：
Watanabe A;Kamata M;Shimizu T;Uchida H;Sakurai E;Suzuki S;Nakajima H;Niimura Y;Ito M;Egawa S;Nagata M;Fukaya S;Hayashi K;Tanaka T;Ishikawa T;Tada Y
银屑病的特征是皮肤血管分布增加，表明异常血管生成与银屑病的发病机制有关。银屑病患者血管生成相关因子的数据有限。我们探讨了银屑病患者血清中血管生成相关因子的水平，并研究了其与临床严重程度和实验室数据的相关性。本研究纳入了2013年4月至2018年4月在我院就诊的银屑病患者和健康对照。采用LEGENDplex测定血清血管生成素-1、碱性成纤维细胞生长因子（FGF）、表皮生长因子（EGF）、血小板内皮细胞粘附分子（PECAM）-1、胎盘生长因子和血管内皮生长因子（VEGF）水平。分析了10名健康对照、18名寻常型银屑病（PsV）、24名银屑病关节炎（PsA）和13名泛发性脓疱型银屑病（GPP）患者的血清样本。PsV、PsA和GPP患者的血清血管生成素-1水平升高。GPP患者血清VEGF水平高于健康对照组。相反，PsV、PsA和GPP患者的血清EGF和PECAM-1水平低于健康对照组。PsA和GPP患者的血清FGF-碱性水平低于健康对照组。全身治疗后，PsA和GPP患者的FGF-basic、PsA患者的PECAM-1和GPP患者的VEGF的血清水平接近健康对照的相应水平。GPP患者的血清FGF-碱性水平与银屑病面积和严重程度指数以及循环嗜酸性粒细胞数量呈正相关。GPP患者血清VEGF水平与血清C反应蛋白（CRP）水平、红细胞沉降率呈正相关，与血清白蛋白水平呈负相关。总之，我们的探索性研究表明，银屑病影响某些血管生成相关因子的血清水平。其中一些因素可能是治疗结果、临床严重程度和全身炎症的生物标志物。
Psoriasis is characterized by increased dermal vascularity, indicating that aberrant angiogenesis is associated with the pathogenesis of psoriasis. Data on angiogenesis‐related factors in psoriasis patients are limited. We explored serum levels of angiogenesis‐related factors in patients with psoriasis, and investigated their association with clinical severity and laboratory data. Psoriasis patients visiting our hospital from April 2013 to April 2018 and healthy controls were included in this study. Serum levels of angiopoietin‐1, fibroblast growth factor (FGF)‐basic, epidermal growth factor (EGF), platelet endothelial cell adhesion molecule (PECAM)‐1, placental growth factor, and vascular endothelial growth factor (VEGF) were measured by LEGENDplex. Serum samples obtained from 10 healthy controls, 18 patients with psoriasis vulgaris (PsV), 24 patients with psoriatic arthritis (PsA), and 13 patients with generalized pustular psoriasis (GPP) were analyzed. The serum angiopoietin‐1 level was elevated in the PsV, PsA, and GPP patients. GPP patients had a higher serum VEGF level than healthy controls. In contrast, serum levels of EGF and PECAM‐1 were lower in the PsV, PsA, and GPP patients than in healthy controls. The serum FGF‐basic level was lower in the PsA and GPP patients than in healthy controls. Serum levels of FGF‐basic in PsA and GPP patients, PECAM‐1 in PsA patients, and VEGF in GPP patients became closer to the respective levels in healthy controls after systemic therapy. The serum FGF‐basic level was positively correlated with the psoriasis area and severity index and the number of circulating eosinophils in GPP patients. The serum VEGF level was correlated positively with the serum C‐reactive protein (CRP) level and erythrocyte sedimentation rate, and negatively with the serum albumin level in GPP patients. In conclusion, our exploratory study revealed that psoriasis affects serum levels of certain angiogenesis‐related factors. Some of these factors could be biomarkers of treatment outcomes, clinical severity, and systemic inflammation.