Neural correlates of auditory temporal-interval discrimination in cats
Neural correlates of auditory temporal-interval discrimination in cats
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猫听觉时间间隔辨别的神经相关性
DOI：
10.1016/j.bbr.2010.06.013
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发表时间：
2010-12-20
影响因子：
2.7
通讯作者：
Sato, Yu
中科院分区：
文献类型：
--
作者：
Liu, Yongchun;Qin, Ling;Sato, Yu
听觉时间线索在言语感知中非常重要：然而，即使是一个简单的时间任务（如间隔辨别）的神经相关性仍然不清楚，主要是由于缺乏相同物种的心理物理和电生理实验的可比数据。为了解决这个问题，我们测量了猫的行为和神经反应。通过呈现两个相同的纯音标记来测试猫区分声音间隔差异的能力，这些标记被10至320 ms持续时间范围内的间隔打断。3名被试均能准确区分80-320 ms和10 ms的音调（正确率> 75%），但不能区分20-40 ms和10 ms的音调。在其他三只清醒猫的初级听觉皮层（A1）记录了对相同刺激的神经反应。与以前的研究一致，我们发现大多数A1神经元对第二个音调表现出抑制反应，并且抑制量一般随着音调间隔的减少而增加。神经测量学分析表明，神经反应可以用来区分的intertone间隔，而辨别性能是依赖于时间精度读取的神经信息。当以100 ms箱大小分析锋电位活动时，80%的神经测量功能与猫的心理测量功能相匹配，这表明A1活动与间隔感知之间可能存在相关性。(C)2010 Elsevier B.V.保留所有权利。
Auditory temporal cues are very important in the perception of speech: nevertheless, the neural correlates underlying even a simple temporal task, such as interval discrimination, remain unclear, mainly due to the lack of comparable data of psychophysical and electrophysiological experiments in the same species. To address this, we measured both behavioral and neural responses in cats. Cats' ability to discriminate differences in sound intervals was tested by presenting two identical pure tone markers interrupted by intervals ranging from 10 to 320 ms duration. All three subjects could accurately discriminate tones of 80-320 ms interval from those of 10 ms interval (correct rate > 75%), but could not discriminate 20-40 ms interval from 10 ms interval. Neural responses to the same stimuli were recorded in the primary auditory cortex (A1) of three others awake cats. Consistent with previous studies, we found that the majority of A1 neurons showed a suppressed response to the second tone, and the amount of suppression generally increased with the decrease of intertone interval. Neurometric analysis revealed that neural responses could be used to discriminate the intertone interval, while discrimination performance was dependent on temporal precision to read the neural information. When spike activities were analyzed by 100 ms bin size, 80% of neurometric functions matched the cats' psychometric function, suggesting a possible correlation between A1 activities and interval perception. (C) 2010 Elsevier B.V. All rights reserved.