Pesticide/environmental exposures and Parkinson's disease in East Texas.
Pesticide/environmental exposures and Parkinson's disease in East Texas.
复制标题
DOI：
10.1080/10599240801986215
复制
发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Shepherd, Sara
中科院分区：
文献类型：
--
作者：
Dhillon, Amanpreet S;Tarbutton, G Lester;Shepherd, Sara
流行病学证据表明，杀虫剂和其他环境暴露可能在特发性帕金森病(PD)的病因学中起作用。然而，几乎没有关于特定农药产品相关风险的人类数据，包括有机农药，如含有PD的鱼藤酮。使用病例对照设计，这项研究检查了在东得克萨斯州人群中暴露于农药产品、诸如鱼藤酮等有机杀虫剂以及其他职业和环境暴露对帕金森病风险的自我报告。结果显示，过去一年在园艺中使用有机农药如鱼藤酮(OR=10.9；95%CI=2.5-48.0)和过去使用任何鱼藤酮(OR=10.0；95%CI=2.9-34.3)显著增加了患帕金森病的风险。使用毒死蜱产品(OR=2.0；95%CI=1.02-3.8)、过去在电子厂工作(OR=5.1；95%CI=1.1-23.6)和接触氟化物(OR=3.3；95%CI=1.03-10.3)也与显著增加的风险有关。接触镉(OR=5.3；95%CI=0.6~44.9)、接触百草枯(OR=3.5；95%CI=0.4~31.6)、在农场动物/动物区域和农业生产过程中使用杀虫剂(OR=4.4；95%CI=0.5~38.1)是帕金森病发病风险增加的趋势。吸烟、饮酒和吃鱼与降低风险有关。总而言之，这项研究表明，在这一人群中，与有机农药(如鱼藤酮和某些其他农药)和环境暴露相关的帕金森病风险增加。
Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.