Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes.
Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes.
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DOI：
10.1523/jneurosci.3363-08.2009
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发表时间：
2009-02-11
期刊：
影响因子：
--
通讯作者：
Critchley HD
中科院分区：
文献类型：
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作者：
Gray MA;Rylander K;Harrison NA;Wallin BG;Critchley HD
中枢神经对环境刺激的处理需要将感觉信息与心血管功能的持续自主控制相结合。心脏和压力感受器活动的节律性反馈动态地有助于稳态自主控制。我们研究了短暂的体感刺激的处理如何在心脏周期中改变，从而引起身体状态的不同变化。通过脑功能磁共振成像和无创心脏搏动监测，我们发现心脏收缩期前和早期的刺激引起了杏仁核、前脑岛和脑桥内神经活动的不同变化，并对血压产生不同的影响。收缩期早期的刺激可抑制血压升高。心率变异性的个体差异预测了导水管周围灰质、杏仁核和脑岛内不同心脏定时反应的大小。我们的研究结果强调了皮质、边缘和脑干水平的体感和相压感受器信息的整合，与疼痛控制、高血压和焦虑的机制相关。
Central nervous processing of environmental stimuli requires integration of sensory information with ongoing autonomic control of cardiovascular function. Rhythmic feedback of cardiac and baroreceptor activity contributes dynamically to homeostatic autonomic control. We examined how the processing of brief somatosensory stimuli is altered across the cardiac cycle to evoke differential changes in bodily state. Using functional magnetic resonance imaging of brain and noninvasive beat-to-beat cardiovascular monitoring, we show that stimuli presented before and during early cardiac systole elicited differential changes in neural activity within amygdala, anterior insula and pons, and engendered different effects on blood pressure. Stimulation delivered during early systole inhibited blood pressure increases. Individual differences in heart rate variability predicted magnitude of differential cardiac timing responses within periaqueductal gray, amygdala and insula. Our findings highlight integration of somatosensory and phasic baroreceptor information at cortical, limbic and brainstem levels, with relevance to mechanisms underlying pain control, hypertension and anxiety.