Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development.
Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development.
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DOI：
10.1016/j.ydbio.2010.03.011
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发表时间：
2010-06-01
影响因子：
2.7
通讯作者：
Tsang, Michael
中科院分区：
文献类型：
--
作者：
Znosko, Wade A.;Yu, Shibin;Thomas, Kirk;Molina, Gabriela A.;Li, Chengjian;Tsang, Warren;Dawid, Igor B.;Moon, Anne M.;Tsang, Michael
Fibroblast Growth Factors (FGFs) are secreted molecules that activate the RAS/mitogen-activated protein kinase (MAPK) signaling pathway. In zebrafish development, FGF signaling is responsible for establishing dorsal polarity, maintaining the isthmic organizer, and cardiac ventricle formation. Because several ETS factors are known transcriptional mediators of MAPK signaling, we hypothesized that these factors function to mediate FGF signaling processes. In zebrafish, the simultaneous knock-down of three Pea3 ETS proteins, Etv5, Erm, and Pea3, produced phenotypes reminiscent of embryos deficient in FGF signaling. Morphant embryos displayed both cardiac and left/right patterning defects as well as disruption of the isthmic organizer. Furthermore, the expression of FGF target genes was abolished in Pea3 ETS depleted embryos. To understand how FGF signaling and ETS factors control gene expression, transcriptional regulation of dusp6 was studied in mouse and zebrafish. Conserved Pea3 ETS binding sites were identified within the Dusp6 promoter, and reporter assays showed that one of these sites is required for dusp6 induction by FGFs. We further demonstrated the interaction of Pea3 ETS factors with the Dusp6 promoter both in vitro and in vivo. These results revealed the requirement of ETS factors in transducing FGF signals in developmental processes.
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影响因子：
1.5
作者：
Draper, BW;Morcos, PA;Kimmel, CB
通讯作者：
Kimmel, CB
DUSP6/MKP-3对FGF信号传导的负反馈调节由ERK1/2驱动，并由ETS因子与DUSP6/MKP-3基因启动子内的保守位点结合介导。
DOI：
10.1042/bj20071512
发表时间：
2008-06-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Ekerot M;Stavridis MP;Delavaine L;Mitchell MP;Staples C;Owens DM;Keenan ID;Dickinson RJ;Storey KG;Keyse SM
通讯作者：
Keyse SM
影响因子：
2.6
作者：
Dickinson, RJ;Eblaghie, MC;Morriss-Kay, GM
通讯作者：
Morriss-Kay, GM
影响因子：
8
作者：
Brown, LA;Amores, A;Sharrocks, AD
通讯作者：
Sharrocks, AD
影响因子：
4.6
作者：
Herzog, W;Sonntag, C;Hammerschmidt, M
通讯作者：
Hammerschmidt, M