Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study
Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study
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DOI：
10.1016/j.atherosclerosis.2011.10.018
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发表时间：
2012-04-01
期刊：
影响因子：
5.3
通讯作者：
Suzuki, Takahiko
中科院分区：
文献类型：
--
作者：
Rathore, Sudhir;Terashima, Mitsuyasu;Suzuki, Takahiko
背景：关于斑块成分和重塑指数(RI)之间的联系，已有相互矛盾的数据报道。本研究的目的是评价光学相干断层成像(OCT)获得的斑块形态与动脉重建的关系。方法和结果：对47例患者94个病变的相应部位进行OCT和血管内超声成像。OCT斑块特征包括脂质含量、纤维帽厚度、薄帽纤维动脉粥样硬化瘤(TCFA)、斑块破裂、血栓、钙化和侵蚀。与中度/负性重塑(RI<；1.0)相比，正性重塑(RI>；1.0)与更高的脂池(2.86+/-0.42vs.2.20+/-0.78；p<；0.001)、较薄的纤维帽(47.86+/-25.43mvs.74.41+/-32.41mm2；p<；0.001)、TCFA>；3 mm(82.1%对22.7%；p<；0.001)相关。斑块破裂和血栓(42.8%vs.19.7%；p=0.024)，以及较高的斑块负荷(73.7%vs.70.7；p=0.048)。有钙化和斑块侵蚀的冠状动脉病变无明显差异。结论：冠状动脉重塑阳性的冠状动脉病变易损斑块和斑块破裂的发生率较高。这可能解释了不稳定冠脉综合征与正向重构之间的相关性。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Conflicting data have been reported about the association between plaque composition and remodelling index (RI). The aim of this study is to evaluate the relationship between plaque morphology obtained by optical coherence tomography (OCT) and arterial remodelling.Methods and results: OCT and intravascular ultrasound imaging pull back was performed at corresponding sites on 94 lesions in 47 patients. OCT plaque characteristics for lipid content, fibrous cap thickness, thin-cap fibroatheroma (TCFA), plaque rupture, thrombus, calcification and erosion were derived using validated criteria. Compared with intermediate/negative remodelling (RI < 1.0), positive remodelling (RI > 1.0) was associated with presence of higher lipid pool (2.86 +/- 0.42 vs. 2.20 +/- 0.78; p < 0.001), thin fibrous cap (47.86 +/- 25.43 mu m vs. 74.41 +/- 32.41 mu m; p < 0.001), TCFA > 3 mm (82.1% vs. 22.7%; p < 0.0001), plaque rupture and thrombus (42.8% vs. 19.7%; p = 0.024), and higher plaque burden (73.70 vs. 70.70; p = 0.048). No difference was observed in the presence of calcification and plaque erosions.Conclusions: Coronary lesions with positive remodelling show higher incidences of vulnerable plaque and plaque rupture across the lesion length. This potentially explains the correlation between unstable coronary syndromes and positive remodelling. (C) 2011 Elsevier Ireland Ltd. All rights reserved.