The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function
The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function
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儿童和青少年期全身照射和骨髓移植对生长和内分泌功能的影响
DOI：
10.1111/j.1365-2141.1987.tb06163.x
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发表时间：
1987
影响因子：
6.5
通讯作者：
P. Plowman
中科院分区：
文献类型：
--
作者：
A. Leiper;R. Stanhope;T. Lau;D. Grant;H. Blacklock;J. Chessells;P. Plowman
总结。对17例(男性11例，女性6例)急性白血病和骨髓增生性疾病的儿童进行了生长发育和内分泌功能障碍的调查。所有患者在1.5~3.8(平均2.2)年前接受了环磷酰胺制备的骨髓移植和单次全身照射(900~1000cGy)。大多数儿童表现出生长障碍，这是由多种原因引起的。10名患者，其中8名曾接受预防性颅脑照射，根据胰岛素诱导的低血糖导致的生长激素反应降低，有生长激素缺乏的证据。3例患者对静脉注射200μg GHRH(1-29)NH2的生长激素反应显示有下丘脑损害。性腺功能衰竭是常见的，通过基础促性腺激素和性类固醇浓度进行临床和生化评估。所有四名青春期(10.6-14.1岁)的女孩都患有卵巢衰竭，需要性激素替代。在8名青春期(12.3-18.3岁)的男孩中，有两名患有睾丸衰竭，需要补充性类固醇。这两人之前都曾接受过睾丸照射。其他5人性腺功能受损，1人间质细胞功能正常。
Summary. Seventeen children (11 M, 6 F) with acute leukaemia and myeloproliferative disorders were investigated for growth and endocrine dysfunction. All had undergone bone marrow transplantation prepared with cyclophos‐phamide and single fraction total body irradiation (900–1000 cGy) between 1.5 and 3.8 (mean 2.2) years previously. The majority of children exhibited growth failure, which was of multiple aetiology. Ten patients, of whom eight had had previous prophylactic cranial irradiation, had evidence of growth hormone deficiency based on the reduced growth hormone response to insulin induced hypoglycaemia. Three patients had evidence of hypothalamic damage as shown by their growth hormone response to 200μg GHRH (1–29) NH2 intravenously. Gonadal failure was common, assessed clinically, and biochemically by basal gonadotrophin and sex steroid concentrations. All four girls of adolescent age (10.6–14.1 years) had ovarian failure requiring sex steroid replacement. Of the eight boys of adolescent age (12.3–18.3 years), two had testicular failure requiring sex steroid supplements. Both of these had had previous testicular irradiation. Five others had compensated gonadal failure, and one had normal Leydig cell function.
影响因子：
20.3
作者：
Sanders,JE;Pritchard,S;Mahoney,P;Amos,D;Buckner,CD;Witherspoon,RP;Deeg,HJ;Doney,KC;Sullivan,KM;Appelbaum,FR
通讯作者：
Appelbaum,FR
DOI：
10.1016/0002-9343(82)90411-9
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Sklar,CA;Kim,TH;Ramsay,NK
通讯作者：
Ramsay,NK