Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
复制标题
抑制SARS-CoV-2细胞病变作用的化合物的药物再利用筛选。
DOI：
10.3389/fphar.2020.592737
复制
发表时间：
2020
影响因子：
5.6
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Chen CZ;Shinn P;Itkin Z;Eastman RT;Bostwick R;Rasmussen L;Huang R;Shen M;Hu X;Wilson KM;Brooks BM;Guo H;Zhao T;Klump-Thomas C;Simeonov A;Michael SG;Lo DC;Hall MD;Zheng W
药物再利用是一种快速确定治疗新出现的传染病（如COVID-19）的疗法的方法。为了解决对治疗方案的迫切需求，我们使用SARS-CoV-2细胞病变试验对8，810种批准和研究药物，基于机制的生物活性化合物和天然产物进行了定量高通量筛选。共鉴定和确认了319个化合物具有抗SARS-CoV-2活性，其中包括91个已批准药物和49个研究药物。其中230个化合物的抗SARS-CoV-2活性，其中38个是已批准的药物，以前没有报道过。氯普噻吨、甲氨曲美嗪和哌拉嗪是FDA批准的三种最有效的抗SARS-CoV-2药物。这三个化合物以前没有报道具有抗SARS-CoV-2活性，尽管它们对SARS-CoV和埃博拉病毒的抗病毒活性已被报道。这些结果表明，这一全面的数据集是药物再利用工作的有用资源，包括为SARS-CoV-2临床试验设计新的药物组合。
Drug repurposing is a rapid approach to identify therapeutics for the treatment of emerging infectious diseases such as COVID-19. To address the urgent need for treatment options, we carried out a quantitative high-throughput screen using a SARS-CoV-2 cytopathic assay with a compound collection of 8,810 approved and investigational drugs, mechanism-based bioactive compounds, and natural products. Three hundred and nineteen compounds with anti-SARS-CoV-2 activities were identified and confirmed, including 91 approved drugs and 49 investigational drugs. The anti-SARS-CoV-2 activities of 230 of these confirmed compounds, of which 38 are approved drugs, have not been previously reported. Chlorprothixene, methotrimeprazine, and piperacetazine were the three most potent FDA-approved drugs with anti-SARS-CoV-2 activities. These three compounds have not been previously reported to have anti-SARS-CoV-2 activities, although their antiviral activities against SARS-CoV and Ebola virus have been reported. These results demonstrate that this comprehensive data set is a useful resource for drug repurposing efforts, including design of new drug combinations for clinical trials for SARS-CoV-2.
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影响因子：
4.7
作者：
Ianevski, Aleksandr;Yao, Rouan;Kainov, Denis E.
通讯作者：
Kainov, Denis E.
影响因子：
2.9
作者：
MAGUIRE, KP;NORMAN, TR;SCOGGINS, BA
通讯作者：
SCOGGINS, BA
影响因子：
13.2
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Kouznetsova, Jennifer;Sun, Wei;Martinez-Romero, Carles;Tawa, Gregory;Shinn, Paul;Chen, Catherine Z.;Schimmer, Aaron;Sanderson, Philip;McKew, John C.;Zheng, Wei;Garcia-Sastre, Adolfo
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Garcia-Sastre, Adolfo
影响因子：
17.1
作者：
Lin, Grant L.;Wilson, Kelli M.;Monje, Michelle
通讯作者：
Monje, Michelle
影响因子：
6.7
作者：
Heaton, Nicholas S.
通讯作者：
Heaton, Nicholas S.