Anakinra for Difficult-to-Treat Neutrophilic Panniculitis: IL-1 Blockade as a Promising Treatment Option for Neutrophil-Mediated Inflammatory Skin Disease
Anakinra for Difficult-to-Treat Neutrophilic Panniculitis: IL-1 Blockade as a Promising Treatment Option for Neutrophil-Mediated Inflammatory Skin Disease
复制标题
阿那白滞素 (Anakinra) 治疗难以治疗的中性粒细胞性脂膜炎：IL-1 阻断作为中性粒细胞介导的炎症性皮肤病的一种有前途的治疗选择
作者：
D. Lipsker;C. Perrigouard;A. Foubert;B. Cribier
嗜酸性脂膜炎的治疗可能具有挑战性。我们报告一位患有难治性嗜酸性脂膜炎的病人，他对IL-1拮抗剂阿那白滞素的短期治疗有惊人的反应。一名61岁女性，有12年严重发热性嗜中性脂膜炎病史，有类固醇诱导的胰腺炎和抗疟药和氨苯砜治疗下危及生命的高铁血红蛋白血症的个人病史。当她出现新的耀斑时，她通过皮下注射100 mg阿那白滞素15天的疗程成功治疗。这是首个证实阿那白滞素治疗嗜酸性脂膜炎有效性的报告。它扩展了IL-1抑制在嗜中性粒细胞性皮肤病领域，或更一般地，在嗜中性粒细胞介导的全身性疾病中的潜在适应症。它强调了IL-1在这些疾病中的潜在致病性参与，这是自身炎症的标志，并支持它们在主要涉及先天免疫系统的疾病中的疾病分类。
The treatment of neutrophilic panniculitis can be challenging. We report a patient with a difficult-to-treat neutrophilic panniculitis who had a spectacular response to a short treatment course with the IL-1 antagonist anakinra. A 61-year-woman had a 12-year history of a serious febrile neutrophilic panniculitis and a personal history of steroid- induced pancreatitis and life-threatening methemoglobinemia under antimalarials and dapsone. When she developed a new flare, she was treated successfully with a 15-day course of subcutaneously administered injections of 100 mg anakinra. This observation is the first report attesting the efficiency of anakinra in neutrophilic panniculitis. It expands the potential indications of IL-1 inhibition in the field of the neutrophilic dermatoses, or more generally, in neutrophil-mediated systemic diseases. It underscores the potential pathogenic involvement of IL-1 in those diseases, a hallmark of autoinflammation, and supports their nosologic classification among diseases involving primarily the innate immune system.
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
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作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R