The Epidemiology of Myasthenia Gravis in Korea.
The Epidemiology of Myasthenia Gravis in Korea.
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DOI：
10.3349/ymj.2016.57.2.419
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发表时间：
2016-03
影响因子：
2.4
通讯作者：
Kim SM
中科院分区：
文献类型：
--
作者：
Lee HS;Lee HS;Shin HY;Choi YC;Kim SM
韩国尚未进行重症肌无力（MG）的流行病学研究。本研究的目的是估计韩国MG的患病率和发病率。检索了2010年至2014年的健康保险审查和评估（HIRA）数据，以查找国际疾病分类第10版定义的MG代码。在确定MG病例后，我们根据HIRA数据库和韩国人口数据估计MG的患病率和年发病率。在研究期间，确定了10138例MG病例。2010年MG患病率为10.42例/10万人，2014年每年增加至12.99例/10万人。2011年至2014年MG的平均发病率为0.69例/10万人年。老年人患病率和发病率较高（≥50岁）年龄组比年轻（<50岁）年龄组[患病率：每10万人9.26对19.24，相对风险2.077，95%置信区间（CI）1.976-2.183，p<0.001;发病率：0.47 vs. 1.18/100000，相对风险2.490，95%CI 2.006-3.091，p<0.001]。该研究是韩国首次以人群为基础的MG流行病学研究。MG的患病率和发病率与既往研究结果一致。我们发现MG的患病率增加，老年MG患者占优势。
An epidemiological study of myasthenia gravis (MG) has not been performed in Korea. The purpose of this study was to estimate the prevalence and incidence of MG in Korea. Health Insurance Review and Assessment (HIRA) data from 2010 to 2014 were searched for MG codes as defined by the International Classification of Diseases, 10th revision. After identifying MG cases, we estimated the prevalence and annual incidence of MG based on the HIRA database and Korean population data. During the study period, 10138 MG cases were identified. The prevalence of MG was 10.42 cases per 100000 people in 2010 and this increased every year to 12.99 cases per 100000 people in 2014. The average incidence of MG between 2011 and 2014 was 0.69 cases per 100000 person-years. The prevalence and incidence were higher in the older (≥50 years) age group than in the younger (<50 years) age group [prevalence: 9.26 vs. 19.24 per 100000, relative risk 2.077, 95% confidence interval (CI) 1.976-2.183, p<0.001; incidence: 0.47 vs. 1.18 per 100000, relative risk 2.490, 95% CI 2.006-3.091, p<0.001]. This study was the first nationwide population-based epidemiological study of MG in Korea. The prevalence and incidence of MG were consistent with those of previous studies. We found an increase in the prevalence of MG and a predominance of elderly MG patients.