In utero alcohol exposure and prediction of alcohol disorders in early adulthood - A birth cohort study
In utero alcohol exposure and prediction of alcohol disorders in early adulthood - A birth cohort study
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DOI：
10.1001/archpsyc.63.9.1009
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发表时间：
2006-09-01
影响因子：
--
通讯作者：
Bor, William
中科院分区：
文献类型：
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作者：
Alati, Rosa;Al Mamun, Abdullah;Bor, William
背景：胎儿酒精暴露在成年早期酒精障碍发生中的作用知之甚少。目的：研究怀孕早期和晚期母亲饮酒对后代酒精障碍发病时间的独立影响。设计：马特-昆士兰大学怀孕及其结局研究(MUSP)的后续研究，这是一项基于人群的出生队列研究，于1981年在澳大利亚布里斯班开始，旨在研究母亲酒精暴露与酒精障碍发病的关系。母亲和孩子在出生时、6个月以及最初采访后的5、14和21年后进行了跟踪调查。在怀孕前、怀孕早期和晚期以及在5年和14年的随访中对母亲的酒精使用进行了评估。使用终生版的综合国际诊断访谈-计算机化版本评估成年早期的酒精障碍。设置：基于人群的出生队列研究。参与者：2138名参与者的子样本，他们在21年的随访中有完整的数据。主要观察指标：从青春期到21岁开始酒精障碍。结果：宫内接触3杯或3杯以上的酒精与酒精障碍有关。在21岁时发生早发性酒精障碍的完全调整的优势比(95%可信区间)是2.95(1.62-5.36)，在怀孕早期接触母亲饮酒的人是1.35(0.69-2.63)。妊娠早期的酒精暴露与迟发性酒精障碍也有很强的相关性(优势比，3.29[95%可信区间，1.74-6.24])。结论：我们的结果支持成人酒精障碍的生物学起源，并表明这种联系不能仅仅由儿童和青春期的母亲饮酒或吸烟或其他干预因素来解释。需要进一步的研究来了解这种联系背后的机制。
Context: Little is known about the contribution of fetal alcohol exposure to the development of alcohol disorders in early adulthood.Objective: To examine the independent effect of maternal alcohol use during early vs late periods in pregnancy on the time of onset of alcohol disorders in offspring.Design: Follow-up study of the Mater-University of Queensland Study of Pregnancy and Its Outcomes (MUSP), a population-based birth cohort study commenced in Brisbane, Australia, in 1981 and designed to examine the association of maternal alcohol exposure with the onset of alcohol disorders. Mothers and children were followed up at birth, 6 months, and 5, 14, and 21 years after the initial interview. Maternal alcohol use was assessed before pregnancy, in early and late pregnancy, and at the 5- and 14-year follow-up visits. Alcohol disorders in early adulthood were assessed at age 21 years using the lifetime version of the Composite International Diagnostic Interview-computerized version.Setting: Population-based birth cohort study.Participants: A subsample of 2138 participants for whom complete data were available at the 21-year follow-up.Main Outcome Measure: Onset of alcohol disorder from adolescence to 21 years of age.Results: In utero alcohol exposure of 3 or more glasses was associated with alcohol disorders. The fully adjusted odds ratios (95% confidence intervals) of developing early-onset alcohol disorders at age 21 years were 2.95 (1.62-5.36) for those exposed to maternal drinking in early pregnancy and 1.35 (0.69-2.63) for those exposed in late pregnancy. There was also a strong association between alcohol exposure in early pregnancy and late-onset alcohol disorders (odds ratio, 3.29 [95% confidence interval, 1.74-6.24]).Conclusions: Our results provide support for a biological origin of adult alcohol disorders and suggest that the association is not explained solely by maternal drinking or smoking during childhood and adolescence or other intervening factors. Further research is needed to understand the mechanisms underlying the association.