Prevalence and predictors of research participant eligibility criteria in alcohol treatment outcome studies, 1970-98
Prevalence and predictors of research participant eligibility criteria in alcohol treatment outcome studies, 1970-98
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DOI：
10.1111/j.1360-0443.2005.01175.x
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发表时间：
2005-09-01
期刊：
影响因子：
6
通讯作者：
Finney, JW
中科院分区：
文献类型：
--
作者：
Humphreys, K;Weingardt, KR;Finney, JW
目的描述的资格标准（即研究参与者的纳入和排除规则），在酒精治疗结果research.Design的预测，并确定其使用的683酒精治疗结果的研究在1970年和1998年之间进行的资格标准可靠地编码成14个一般类别。结果患者最常被裁定为不符合资格的研究，因为他们的酒精问题的水平（39.1%的研究），共病精神问题（37.8%），既往或同时使用酒精治疗（31.8%），同时发生的医疗条件（31.6%），因为他们被认为是不遵守和无动力（31.5%）。从20世纪70年代到20世纪90年代，研究中采用的合格标准数量增加，并且与美国国家酒精滥用和酒精中毒研究所（NIAAA）和私营部门的资助呈正相关，缺乏住院/住院治疗条件，存在药物治疗，以及使用随机，多条件设计。具有博士学位的主要研究者使用更多的资格标准比那些较低degrees.Conclusion参与者的资格标准被广泛采用在酒精治疗结果的研究，并在不同的历史时期，资助者和研究设计显着不同。研究者应更全面地报告受试者资格标准和排除患者的详细信息，并评估资格标准如何影响治疗结局研究的成本、可行性和普遍性。
Aims To describe the eligibility criteria (i.e. study participant inclusion and exclusion rules) employed in alcohol treatment outcome research and to identify predictors of their use.Design The eligibility criteria of 683 alcohol treatment outcome studies conducted between 1970 and 1998 were coded reliably into 14 general categories. Predictors of the use of eligibility criteria were then examined.Findings Patients were most often ruled ineligible for research studies because of their level of alcohol problems (39.1% of studies), comorbid psychiatric problems (37.8%), past or concurrent utilization of alcohol treatment (31.8%), co-occurring medical conditions (31.6%), and because they were deemed non-compliant and unmotivated (31.5%). The number of eligibility criteria employed in studies increased from the 1970s through the 1990s, and was positively associated with funding from the US National Institute of Alcohol Abuse and Alcoholism (NIAAA) and from the private sector, lack of an inpatient/residential treatment condition, presence of a pharmacotherapy, and use of a randomized, multiple-condition design. Principal investigators with doctoral degrees used more eligibility criteria than those with lower degrees.Conclusion Participant eligibility criteria are extensively employed in alcohol treatment outcome research, and vary significantly across historical periods, funders and research designs. Researchers should report the details of subject eligibility criteria and excluded patients more fully, and, evaluate how eligibility criteria affect the cost, feasibility, and generalizability of treatment outcome research.