Circular RNAs: analysis, expression and potential functions
Circular RNAs: analysis, expression and potential functions
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DOI：
10.1242/dev.128074
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发表时间：
2016-06-01
期刊：
影响因子：
4.6
通讯作者：
Salzman, Julia
中科院分区：
文献类型：
--
作者：
Barrett, Steven P.;Salzman, Julia
就在几年前，人们还认为真核基因产生的主要RNA异构体是信使RNA的变体，在基因表达中起着中间体的作用。然而，在2012年初，一个令人惊讶的发现被发现：环状RNA（circRNA）被证明是数千个人类和小鼠基因的转录产物，并且在数百种情况下构成了主要的RNA亚型。随后的研究表明，circRNA的表达是发育调节的，组织和细胞类型特异性的，并且在真核生命树中共享。这些特征表明这些分子的重要功能。在这里，我们描述了circRNA生物学领域的主要进展，重点是这些分子的调节和功能作用。
Just a few years ago, it had been assumed that the dominant RNA isoforms produced from eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene expression. In early 2012, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree of life. These features suggest important functions for these molecules. Here, we describe major advances in the field of circRNA biology, focusing on the regulation of and functional roles played by these molecules.