Laboratory evaluation of a quaternary ammonium compound (QAC)-based antimicrobial coating used in public transport during the COVID-19 pandemic
Laboratory evaluation of a quaternary ammonium compound (QAC)-based antimicrobial coating used in public transport during the COVID-19 pandemic
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COVID-19 大流行期间公共交通中使用的基于季铵化合物 (QAC) 的抗菌涂层的实验室评估
DOI：
10.1101/2022.10.12.512011
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Aranega-Bou P
中科院分区：
文献类型：
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作者：
Aranega-Bou P
以ϕ6噬菌体作为SARS冠状病毒2的替代品，对英国铁路行业在新冠肺炎疫情期间使用的一种基于季铵化合物的抗菌涂层的杀灭病毒活性进行了评估。在没有干扰物质的情况下，该产品在使用后立即对一些通常用于轨道车厢的材料(不锈钢、高压层压板和塑料)表现出效力(<；3log10降低)，对玻璃表现出不同的效果，对由Terluran 22制成的火车扶手没有效果(<；3log10降低)。如果在涂抹产品后，表面保持不受干扰，则抗菌涂层在所有材料上保持至少28天的效力，在涂抹后立即生效。然而，无论涂层材料或涂布时间长短，有机残留物(胎牛血清)的存在都会显著降低涂层的抗病毒活性。在有机碎片沉积后用湿布擦拭表面不足以恢复疗效。我们的结论是，该产品在繁忙的多用户环境中可能效果有限，例如公共交通。重要信息本研究评估了一种商用抗菌涂层的性能，该涂层在新冠肺炎疫情期间被英国交通行业使用。虽然该产品最初在某些材料上应用时显示出对抗ϕ6的效果，但当随后沉积有机碎片时，其效果严重减弱，无法通过擦拭(清洁)表面来恢复。这突出了在实验室评估抗菌涂层时包括相关材料和条件的重要性。需要进一步努力为运输业确定适当的感染预防和控制做法。
The virucidal activity of a quaternary ammonium compound (QAC)-based antimicrobial coating used by the UK rail industry during the COVID-19 pandemic was evaluated using the bacteriophage ϕ6 as a surrogate for SARS-CoV-2. Immediately after application and in the absence of interfering substance, the product showed efficacy (>3 log10reduction) on some materials typically used in rail carriages (stainless steel, high pressure laminate and plastic), variable efficacy on glass and no efficacy (<3 log10reduction) on a train armrest made of Terluran 22. If, after application of the product, the surfaces remained undisturbed, the antimicrobial coating retained its efficacy for at least 28 days on all materials where it was effective immediately after application. However, regardless of the material coated or time since application, the presence of organic debris (fetal bovine serum) significantly reduced the viricidal activity of the coating. Wiping the surface with a wetted cloth after organic debris deposition was not sufficient to restore efficacy. We conclude that the product is likely to be of limited effectiveness in a busy multi-user environment such as public transport.ImportanceThis study evaluated the performance of a commercially available antimicrobial coating used by the transport industry in the UK during the COVID-19 pandemic. While the product initially showed efficacy against ϕ6 when applied to some materials, when organic debris was subsequently deposited, the efficacy was severely diminished and could not be recovered through wiping (cleaning) the surface. This highlights the importance of including relevant materials and conditions when evaluating antimicrobial coatings in the laboratory. Further efforts are required to identify suitable infection prevention and control practices for the transport industry.