IgE and IgG antibodies to beta-propiolactone and human serum albumin associated with urticarial reactions to rabies vaccine.
IgE and IgG antibodies to beta-propiolactone and human serum albumin associated with urticarial reactions to rabies vaccine.
复制标题
β-丙内酯和人血清白蛋白的 IgE 和 IgG 抗体与狂犬病疫苗的荨麻疹反应相关。
DOI：
10.1093/infdis/155.5.909
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Reed,CE
中科院分区：
文献类型：
--
作者：
Swanson,MC;Rosanoff,E;Gurwith,M;Deitch,M;Schnurrenberger,P;Reed,CE
We examined the antibody response to a rabies vaccine doubly inactivated with 0.025% β-propiolactone and O.lOJo tri(n)butyl phosphate and stabilized with 2.5% human serum albumin. Antibodies were measured by using the following four antigen preparations: complete doubly inactivated rabies vaccine, rabies vaccine inactivated only with tri(n)butyl phosphate, β-propiolactone and human serum albumin, and human serum albumin alone. The fluid phase of the preparation of β-propiolactone and human serum albumin completely inhibited IgE binding to solid-phase vaccine. Of 21 subjects with urticarial reactions to a booster, 19 had IgE to doubly inactivated vaccine and to β-propiolactone and human serum albumin. None of 27 immunized subjects without urticaria had detectable IgE. In paired pre- and postimmunization sera, IgE appeared in six of seven of the subjects with urticaria and in one of seven nonreactors. These sera did not contain a significant level of IgE to singly inactivated vaccine or to human serum albumin alone.
