ACTIVITY-DEPENDENT CHANGES IN THE INTRINSIC-PROPERTIES OF CULTURED NEURONS
ACTIVITY-DEPENDENT CHANGES IN THE INTRINSIC-PROPERTIES OF CULTURED NEURONS
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DOI：
10.1126/science.8178157
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发表时间：
1994-05-13
期刊：
影响因子：
56.9
通讯作者：
MARDER, E
中科院分区：
文献类型：
--
作者：
TURRIGIANO, G;ABBOTT, LF;MARDER, E
学习和记忆通过神经回路的活动依赖性修改而产生。虽然突触效能的活动依赖性已被广泛研究，但对活动如何塑造神经元的内在电特性知之甚少。龙虾的口胃神经节神经元在接受突触和调制输入时会爆发性放电，但在孤立时会紧张性放电。在文化中的长期隔离改变了他们的内在活动，从紧张性放电到爆发性放电。节律性刺激通过细胞内钙离子浓度升高介导的机制逆转了这种转变。这些数据表明，神经元调节其电导以保持稳定的活动模式，并且神经元的内在特性取决于其最近的激活历史。
Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation.