Frequency of brain tissue donation for research after suicide
Frequency of brain tissue donation for research after suicide
复制标题
自杀后捐献脑组织用于研究的频率
DOI：
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发表时间：
2017
影响因子：
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通讯作者：
P. Magalhães
中科院分区：
文献类型：
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作者：
V. K. Longaray;C. Padoan;P. D. Goi;R. C. da Fonseca;D. C. Vieira;F. H. de Oliveira;F. Kapczinski;P. Magalhães
目的：描述自杀者家属为研究目的捐献脑组织的频率。研究方法：所有向2014年3月至2016年2月期间自杀的18-60岁个人的家属提出的脑组织捐赠请求都包括在内。由于急性创伤导致脑损伤的病例被排除在外。结果：共报告自杀五十六例。其中，24例符合排除标准，另外11例因未发现近亲提供知情同意书而被排除。在剩下的21个病例中，9个病例的脑组织捐赠得到批准（7个病例的组织碎片和2个病例的整个器官）。结论：从自杀病例中捐献脑组织用于研究是可行的。我们样本中42.8%的接受率与国际上关于此类捐赠的数据一致，与神经退行性疾病的接受率相似。
Objectives: To describe the frequency of brain tissue donation for research purposes by families of individuals that committed suicide. Methods: All requests for brain tissue donation to a brain biorepository made to the families of individuals aged 18-60 years who had committed suicide between March 2014 and February 2016 were included. Cases presenting with brain damage due to acute trauma were excluded. Results: Fifty-six cases of suicide were reported. Of these, 24 fulfilled the exclusion criteria, and 11 others were excluded because no next of kin was found to provide informed consent. Of the 21 remaining cases, brain tissue donation was authorized in nine (tissue fragments in seven and the entire organ in two). Conclusions: Donation of brain tissue from suicide cases for research purposes is feasible. The acceptance rate of 42.8% in our sample is in accordance with international data on such donations, and similar to rates reported for neurodegenerative diseases.