Plasma lactate and diabetes risk in 8045 participants of the Atherosclerosis Risk in Communities Study
Plasma lactate and diabetes risk in 8045 participants of the Atherosclerosis Risk in Communities Study
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DOI：
10.1016/j.annepidem.2013.09.005
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发表时间：
2013-12-01
影响因子：
5.6
通讯作者：
Young, J. Hunter
中科院分区：
文献类型：
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作者：
Juraschek, Stephen P.;Selvin, Elizabeth;Young, J. Hunter
目的：氧化能力的决定因素，如健身和肥胖水平，与2型糖尿病密切相关。无论是降低氧化能力本身是一个原因或后果的胰岛素抵抗和糖尿病是unknowed.Methods：我们研究了相关的血浆乳酸，氧化能力的标志物，与事件糖尿病在8045参与者的动脉粥样硬化风险在社区（ARIC）的研究，在基线（1996年至1998年）没有亚临床或诊断糖尿病的历史。事件糖尿病自我报告在每年的电话calls.Results：在中位数随访12年，有1513例糖尿病新发病例。在考克斯比例风险模型中，基线血浆乳酸（每10 mg/dL）与糖尿病显著相关（风险比，1.20; 95%置信区间，1.01-1.43），即使在调整糖尿病风险因素、空腹血糖和胰岛素后。基线乳酸的上四分位数（>= 8.1 mg/dL）与糖尿病风险显著相关（风险比，1.20; 95%置信区间，1.02-1.41），而最低四分位数（
Purpose: Determinants of oxidative capacity, such as fitness and level of adiposity, are strongly associated with type 2 diabetes. Whether decreased oxidative capacity itself is a cause or consequence of insulin resistance and diabetes is unknown.Methods: We examined the association of plasma lactate, a marker of oxidative capacity, with incident diabetes in 8045 participants from the Atherosclerosis Risk in Communities (ARIC) Study with no history of subclinical or diagnosed diabetes at baseline (1996-1998). Incident diabetes was self-reported during annual telephone calls.Results: During a median follow-up of 12 years, there were 1513 new cases of diabetes. In Cox proportional hazards models, baseline plasma lactate (per 10 mg/dL) was significantly associated with diabetes (hazard ratio, 1.20; 95% confidence interval, 1.01-1.43), even after adjustment for diabetes risk factors, fasting glucose, and insulin. The upper quartile of baseline lactate (>= 8.1 mg/dL) was also significantly associated with diabetes risk (hazard ratio, 1.20; 95% confidence interval, 1.02-1.41) compared with the lowest quartile (