PTHrP Rescues ATDC5 Cells From Apoptosis Induced by FGF Receptor 3 Mutation
PTHrP Rescues ATDC5 Cells From Apoptosis Induced by FGF Receptor 3 Mutation
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DOI：
10.1359/jbmr.2003.18.8.1395
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发表时间：
2003-08
影响因子：
6.2
通讯作者：
Y. Yamanaka;Hiroyuki Tanaka;Mio Koike;R. Nishimura;Y. Seino
中科院分区：
文献类型：
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作者：
Y. Yamanaka;Hiroyuki Tanaka;Mio Koike;R. Nishimura;Y. Seino
FGFR3基因中的激活突变导致ACH。在软骨形成细胞系中分析FGFR3突变体对细胞凋亡的影响。ACH软骨细胞表现出明显的凋亡，PTHrP表达下调。通过PTHrP替代来拯救这些细胞意味着这种疾病的潜在疗法。
An activation mutation in the FGFR3 gene causes ACH. The effects of the FGFR3 mutants on apoptosis were analyzed in a chondrogenic cell line. ACH chondrocytes exhibited marked apoptotic with downregulation of PTHrP expression. Rescue of these cells by PTHrP replacement implies a potential therapy for this disorder.