[MicroRNAs and nonresolving inflammation-related cancer].
[MicroRNAs and nonresolving inflammation-related cancer].
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DOI：
10.3969/j.issn.1672-7347.2013.06.014
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发表时间：
2013-06-01
期刊：
影响因子：
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通讯作者：
Li, Guiyuan
中科院分区：
文献类型：
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作者：
Gong, Zhaojian;Zhang, Shanshan;Li, Guiyuan
未消退的炎症和癌症之间的联系已经有了很好的记录。一方面，流行病学证据支持，全世界大约25%的人类癌症是由未消退的炎症引起的。另一方面，炎性细胞存在于大多数(如果不是全部)肿瘤的微环境中。在肿瘤微环境中，炎性细胞和分子几乎影响到癌症的各个方面。MicroRNAs(MiRNAs)通过调控关键基因和相关信号通路，参与炎症相关癌症的发生和发展。进一步研究miRNAs执行其功能的分子机制将对肿瘤的预防、早期诊断和治疗具有重要价值。
The link between nonresolving inflammation and cancer is well documented. On the one hand, epidemiologic evidence supports that approximately 25% of all human cancer worldwide is caused by nonresolving inflammation. On the other hand, inflammatory cells are found in the microenvironment of most, if not all, tumors. In the tumor micro-environment, inflammatory cells and molecules influence almost every aspect of cancer. MicroRNAs (miRNAs) participate in the initiation and progression of nonresolving inflammation-related cancer by regulating the key genes and related signaling pathways. Further investigation into the molecular mechanisms by which miRNAs carry out their functions will be of great value in the prevention, early diagnosis, and treatment of tumors.