Natural products as antidepressants documented in Chinese patents from 1992 to 2013
Natural products as antidepressants documented in Chinese patents from 1992 to 2013
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DOI：
10.1080/10286020.2014.985770
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发表时间：
2015-01
影响因子：
1.7
通讯作者：
Chang-Li Sun;Chang-An Geng;Xiu-Juan Yin;Xiaoyan Huang;Ji-Jun Chen
中科院分区：
文献类型：
--
作者：
Chang-Li Sun;Chang-An Geng;Xiu-Juan Yin;Xiaoyan Huang;Ji-Jun Chen
抑郁症是世界范围内一个严重的精神问题。市场上针对单胺类神经递质的治疗抑郁症的临床治疗药物，由于其不良反应，远远不能令人满意。需要具有不同作用机制和低毒性的新型抗抑郁药物。中药中的天然产物具有多种化学结构和良好的活性，是治疗抑郁症的新来源。本文综述了目前我国专利文献中记载的天然抗抑郁药物。
Depressive disorder is a severe psychiatric problem all over the world. Clinical therapeutic agents for the treatment of depression in the market targeting on monoamine neurotransmitters are far from satisfaction due to their adverse effects. Novel classes of antidepressant agents with different mechanisms and low toxicity are needed. Natural products from traditional Chinese medicines have been revealed as new sources to cure the depressive symptoms with various chemical structures and promising activities. This paper reviews natural products as antidepressants documented in Chinese patents so far.