Attenuation of Allergic Responses Following Treatment with Resveratrol in Anaphylactic Models and IgE-Mediated Mast Cells
Attenuation of Allergic Responses Following Treatment with Resveratrol in Anaphylactic Models and IgE-Mediated Mast Cells
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过敏模型和 IgE 介导的肥大细胞中白藜芦醇治疗后过敏反应的减弱
DOI：
10.1039/c9fo00077a
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发表时间：
2019
期刊：
影响因子：
6.1
通讯作者：
Guang-Ming Liu
中科院分区：
文献类型：
--
作者：
Ya-Fen Zhang;Qing-Mei Liu;Yuan-Yuan Gao;Bo Liu;Hong Liu;Min-Jie Cao;Xian-Wen Yang;Guang-Ming Liu
白藜芦醇广泛存在于植物中，具有多种抗氧化、抗炎和免疫调节作用。然而，关于其抗食物过敏活性的报道很少。在本研究中，我们证明了白藜芦醇(从冷杉中分离出来)可以减少大鼠嗜碱性白血病-2H3细胞β-己糖苷酶和组胺的释放。白藜芦醇不仅能抑制腹泻的发展，上调卵蛋白过敏小鼠的直肠温度，降低血清中特异性免疫球蛋白E、小鼠肥大细胞蛋白酶-1和组胺的水平，而且还能减少卵白蛋白过敏小鼠脾和肠系膜淋巴结中树突状细胞、B细胞和肥大细胞的数量。此外，白藜芦醇抑制骨髓来源细胞β-己糖苷酶和组胺的释放，并减轻肥大细胞介导的被动皮肤过敏反应。这些发现表明，从冷杉中分离出的白藜芦醇可能具有缓解食物过敏或过敏性疾病的潜力。
Resveratrol exists widely in plant species and has a variety of anti-oxidant, anti-inflammatory, and immunomodulatory properties. However, there have been few reports regarding its anti-food allergic activity. In this study, we demonstrated that resveratrol (isolated from Abies georgei) could decrease the release of β-hexosaminidase and histamine in rat basophilic leukemia-2H3 cells. Resveratrol was not only found to suppress the development of diarrhea, up-regulate the rectal temperature of ovalbumin-allergic mice, and decrease the serum level of specific immunoglobulin E, mouse mast cell protease-1 and histamine, but also found to decrease the population of dendritic cells, B cells and mast cells of ovalbumin -allergic mice in the spleen or mesenteric lymph node. Furthermore, resveratrol inhibited the release of β-hexosaminidase and histamine in bone marrow-derived cells and alleviated mast cell-mediated passive cutaneous anaphylaxis reactions. These findings indicated that resveratrol isolated from Abies georgei might have the potential to alleviate food hypersensitivity or allergic disease.