Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
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DOI：
10.1158/1078-0432.ccr-06-1007
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发表时间：
2006-10-15
影响因子：
11.5
通讯作者：
Chirgwin, John M.
中科院分区：
文献类型：
--
作者：
Guise, Theresa A.;Mohammad, Khalid S.;Chirgwin, John M.
某些实体瘤转移到骨并引起骨质溶解和异常的新骨形成。骨破坏和骨形成失调各自的表型代表了一个谱的两端，大多数患者都有这两种表型的证据。肿瘤在骨中生长的机制是复杂的，涉及破骨细胞和成骨细胞的肿瘤刺激以及骨微环境的反应。此外，增加骨吸收的因素，独立于肿瘤，如性类固醇缺乏可能有助于这种恶性循环的肿瘤生长在骨。本文讨论了溶骨性和成骨性骨转移瘤的机制和治疗意义。
Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.