Omics and interspecies interaction.
Omics and interspecies interaction.
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DOI：
10.1111/prd.12354
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发表时间：
2020-11
影响因子：
18.6
通讯作者：
Bhumika Shokeen;M. Dinis;F. Haghighi;N. Tran;R. Lux
中科院分区：
文献类型：
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作者：
Bhumika Shokeen;M. Dinis;F. Haghighi;N. Tran;R. Lux
种间相互作用是生物膜行为、生态和结构的关键决定因素。微生物在转录、蛋白质组学和代谢组学水平上相互之间的细胞反应最终决定了生物膜的特征以及对健康和疾病的相应影响。组学技术的进步彻底改变了我们对微生物群落组成及其整体活动的理解。然而，对生物膜内许多微生物物种之间复杂相互作用的大规模分析目前仍受到技术和生物信息学挑战的阻碍。因此，种间相互作用的研究主要集中在转录和蛋白质组学的变化，发生在一些突出的物种，如牙龈卟啉单胞菌，变形链球菌，白色念珠菌，和其他一些人，与选定的合作伙伴物种的接触。扩展现有的工具是必要的，以增加揭示，虽然有限，这些研究提供了深入了解的性质，个别微生物对他人的存在的反应。这将使我们能够回答一些重要的问题，包括：在复杂的生物膜环境中，哪些微生物间的相互作用协调了无数的合作，协同，拮抗，操纵和其他类型的关系和活动，以及对口腔健康和疾病的影响是什么？
Interspecies interactions are key determinants in biofilm behavior, ecology, and architecture. The cellular responses of microorganisms to each other at transcriptional, proteomic, and metabolomic levels ultimately determine the characteristics of biofilm and the corresponding implications for health and disease. Advances in omics technologies have revolutionized our understanding of microbial community composition and their activities as a whole. Large-scale analyses of the complex interaction between the many microbial species residing within a biofilm, however, are currently still hampered by technical and bioinformatics challenges. Thus, studies of interspecies interactions have largely focused on the transcriptional and proteomic changes that occur during the contact of a few prominent species, such as Porphyromonas gingivalis, Streptococcus mutans, Candida albicans, and a few others, with selected partner species. Expansion of available tools is necessary to grow the revealing, albeit limited, insight these studies have provided into a profound understanding of the nature of individual microbial responses to the presence of others. This will allow us to answer important questions including: Which intermicrobial interactions orchestrate the myriad of cooperative, synergistic, antagonistic, manipulative, and other types of relationships and activities in the complex biofilm environment, and what are the implications for oral health and disease?