The collagen receptor integrins have distinct ligand recognition and signaling functions
The collagen receptor integrins have distinct ligand recognition and signaling functions
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DOI：
10.1016/s0945-053x(00)00076-7
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发表时间：
2000-08-01
期刊：
影响因子：
6.9
通讯作者：
Heino, J
中科院分区：
文献类型：
--
作者：
Heino, J
不同的胶原亚型由特定的细胞表面受体识别。最著名的两种胶原受体是整合素家族的成员，分别命名为α1β1和α2β1。整合素α1β1在平滑肌细胞中含量丰富，而α2β1整合素是上皮细胞和血小板上的主要胶原受体。许多细胞类型，如成纤维细胞、成骨细胞、软骨细胞、内皮细胞和淋巴细胞可能同时表达这两种受体。我们在两个水平上研究了这些整合素的细胞生物学。首先，我们分析了它们的配体结合机制和特异性。其次，我们研究了它们在三维胶原凝胶中的信号功能。这篇简短的综述总结了我们的最新成果。综上所述，我们的数据表明，α1β1和α2β1整合素在配体结合特异性上存在差异。此外，这两个受体连接到不同的信号通路，它们的连接可能会导致相反的细胞反应。(C)2000年Elsevier Science B.V./国际基质生物学学会。版权所有。
Distinct collagen subtypes are recognized by specific cell surface receptors. Two of the best known collagen receptors are members of the integrin family and are named alpha 1 beta 1 and alpha 2 beta 1. Integrin alpha 1 beta 1 is abundant on smooth muscle cells, whereas the alpha 2 beta 1 integrin is the major collagen receptor on epithelial cells and platelets. Many cell types, such as fibroblasts, osteoblasts, chondrocytes, endothelial cells, and lymphocytes may concomitantly express both of the receptors. We have studied the cell biology of these integrins at two levels. First, we have analyzed their ligand binding mechanism and specificity. Second, we have studied their signaling function inside three-dimensional collagen gels. This mini-review summarizes our most recent results. In conclusion, our data indicate that alpha 1 beta 1 and alpha 2 beta 1 integrins have differences in their ligand binding specificity. Furthermore, the two receptors are connected to distinct signaling pathways and their ligation may lead to opposite cellular responses. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.